Phenotypes associated with this allele

• Allele Symbol: Rassf2^tm1Dlim
• Allele Name: targeted mutation 1, Dae-Sik Lim
• Allele ID: MGI:5314787
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rassf2^tm1Dlim/Rassf2^tm1Dlim	B6.Cg-Rassf2^tm1Dlim	MGI:5314794

Genotype
MGI:5314794

hm1

• Allelic Composition: Rassf2^tm1Dlim/Rassf2^tm1Dlim
• Genetic Background: B6.Cg-Rassf2^tm1Dlim

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:181952 )

• beginning at 4 weeks of age

immune system

abnormal thymus epithelium morphology ( J:181952 )

• thinning of cortical thymic epithelial cells

decreased thymus weight ( J:181952 )

thymus hypoplasia ( J:181952 )

decreased leukocyte cell number ( J:181952 )

decreased B cell number ( J:181952 )

• in the thymus, spleen and bone marrow

decreased T cell number ( J:181952 )

• in the thymus, spleen and bone marrow

decreased CD4-positive, alpha-beta T cell number ( J:181952 )

• in the thymus and peripheral blood

decreased CD8-positive, alpha-beta T cell number ( J:181952 )

• in the thymus and peripheral blood

abnormal myeloid leukocyte morphology ( J:181952 )

• reduced numbers of myeloid cells in the thymus, spleen and bone marrow

abnormal osteoclast differentiation ( J:181952 )

• enhanced

decreased osteoclast cell number ( J:181952 )

• impaired due to lack of osteoblasts

abnormal spleen red pulp morphology ( J:181952 )

• mild congestion

decreased spleen weight ( J:181952 )

spleen hypoplasia ( J:181952 )

skeleton

abnormal osteoblast differentiation ( J:181952 )

• impaired

abnormal osteoclast differentiation ( J:181952 )

• enhanced

decreased osteoclast cell number ( J:181952 )

• impaired due to lack of osteoblasts

decreased bone mineral density ( J:181952 )

decreased osteoblast cell number ( J:181952 )

abnormal trabecular bone morphology ( J:181952 )

• increased trabecular bone separation

decreased trabecular bone volume ( J:181952 )

decreased bone trabecula number ( J:181952 )

decreased trabecular bone thickness ( J:181952 )

decreased bone mass ( J:181952 )

osteoporosis ( J:181952 )

abnormal bone mineralization ( J:181952 )

• mice exhibit reduced bone mineral apposition compared with wild-type mice

growth/size/body

decreased body weight ( J:181952 )

• at 2 weeks of age

postnatal growth retardation ( J:181952 )

• at 2 weeks of age

cellular

abnormal osteoblast differentiation ( J:181952 )

• impaired

abnormal osteoclast differentiation ( J:181952 )

• enhanced

liver/biliary system

liver fibrosis ( J:181952 )

• mild periportal fibrosis

hematopoietic system

abnormal thymus epithelium morphology ( J:181952 )

• thinning of cortical thymic epithelial cells

decreased thymus weight ( J:181952 )

thymus hypoplasia ( J:181952 )

decreased common myeloid progenitor cell number ( J:181952 )

decreased bone marrow cell number ( J:181952 )

decreased erythrocyte cell number ( J:181952 )

decreased leukocyte cell number ( J:181952 )

decreased B cell number ( J:181952 )

• in the thymus, spleen and bone marrow

decreased T cell number ( J:181952 )

• in the thymus, spleen and bone marrow

decreased CD4-positive, alpha-beta T cell number ( J:181952 )

• in the thymus and peripheral blood

decreased CD8-positive, alpha-beta T cell number ( J:181952 )

• in the thymus and peripheral blood

decreased hematopoietic stem cell number ( J:181952 )

abnormal myeloid leukocyte morphology ( J:181952 )

• reduced numbers of myeloid cells in the thymus, spleen and bone marrow

abnormal osteoclast differentiation ( J:181952 )

• enhanced

decreased osteoclast cell number ( J:181952 )

• impaired due to lack of osteoblasts

abnormal spleen red pulp morphology ( J:181952 )

• mild congestion

decreased spleen weight ( J:181952 )

spleen hypoplasia ( J:181952 )

endocrine/exocrine glands

abnormal thymus epithelium morphology ( J:181952 )

• thinning of cortical thymic epithelial cells

decreased thymus weight ( J:181952 )

thymus hypoplasia ( J:181952 )