All Phenotypes Mir210<tm1Mtm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mir210^tm1Mtm
targeted mutation 1, Michael McManus
MGI:5314656

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir210^tm1Mtm/Mir210^tm1Mtm	involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/cJ	MGI:6457113

Allelic Composition	Mir210^tm1Mtm/Mir210^tm1Mtm
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/cJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir210^tm1Mtm mutation (1 available); any Mir210 mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:294650 )

N	• normal ureter development and morphology at age P2

abnormal kidney morphology ( J:294650 , J:294650 , J:294650 )

	• normal nephron progenitor proliferation at age P2 (J:294650) • normal nephrogenesis timing at age P3 and P4 (J:294650) • normal kidney morphology at age P0 (J:294650)
	• normal nephron number at age P30 (J:294650)
	• 35% reduction in nephron number at age P30 (J:294650) • increased Lef1 expression at age P2 (J:294650)

decreased nephron number ( J:294650 , J:294650 )

	• normal nephron number at age P30 (J:294650)
	• 35% reductionat age P30 (J:294650) • increased expression of pro-apoptotic Casp8ap2 at age P2 (J:294650)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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