Phenotypes associated with this allele

• Allele Symbol: Clec1b^tm1.1Arte
• Allele Name: targeted mutation 1.1, TaconicArtemis
• Allele ID: MGI:5314117
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gp6^tm1Beni/Gp6^tm1Beni Clec1b^tm1.1Arte/Clec1b^tm1.1Arte Tg(Pf4-icre)Q3Rsko/0	involves: 129 * C57BL/6	MGI:5694695
cn2	Clec1b^tm1.1Arte/Clec1b^tm1.1Arte Tg(Pf4-icre)Q3Rsko/0	involves: C57BL/6	MGI:5314239

Genotype
MGI:5694695

cn1

• Allelic Composition: Gp6^tm1Beni/Gp6^tm1Beni; Clec1b^tm1.1Arte/Clec1b^tm1.1Arte; Tg(Pf4-icre)Q3Rsko/0
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased bleeding time ( J:217963 )

• markedly prolonged tail-bleeding times

hematopoietic system

abnormal platelet cell number ( J:217963 )

• moderately reduced platelet count

reproductive system

decreased litter size ( J:217963 )

• litters of 2-6 mice

• fewer than 35% double homozygotes

immune system

abnormal lymphatic vessel morphology ( J:217963 )

• blood filled lymphatics in the intestine

• more pronounced than in Clec1b^tm1.1Arte single homozygotes

Genotype
MGI:5314239

cn2

• Allelic Composition: Clec1b^tm1.1Arte/Clec1b^tm1.1Arte; Tg(Pf4-icre)Q3Rsko/0
• Genetic Background: involves: C57BL/6

homeostasis/metabolism

abnormal blood coagulation ( J:217963 )

• slight and insignificantly delayed appearance of small thrombi

• vessel occlusion is delayed or absent

abnormal platelet physiology ( J:181715 )

• in the presence of platelets, reduced migration of lymphatic endothelial cells in a transmigration assay is weaker compared to in the presence of control platelets

• platelet disruption of human lymphatic endothelial cells network formation on a matrix is disrupted to a lesser extent compared to when control platelets are used

edema ( J:181715 )

• at E14.5

ascites ( J:181715 )

• around the intestine

hematopoietic system

abnormal platelet physiology ( J:181715 )

• in the presence of platelets, reduced migration of lymphatic endothelial cells in a transmigration assay is weaker compared to in the presence of control platelets

• platelet disruption of human lymphatic endothelial cells network formation on a matrix is disrupted to a lesser extent compared to when control platelets are used

cardiovascular system

abnormal blood vessel morphology ( J:181715 )

• at 8 weeks, dye injection confirms interconnection between lymphatic and blood vessels with rapid spread labeling unlike in control mice

intracranial hemorrhage ( J:181715 )

• brain hemorrhages at E12.5

respiratory system

respiratory system phenotype ( J:181715 )

N • at P0, mice exhibit normal lungs

immune system

abnormal lymphatic vessel morphology ( J:181715 )

• at E14.5, mice exhibit blood-filled vessels unlike control mice

• at 6 to 8 weeks, mice exhibit blood in mesenteric and intestinal lymphatic vessels and intestine proper unlike in control mice

• at 8 weeks, dye injection confirms interconnection between lymphatic and blood vessels with rapid spread labeling unlike in control mice

abnormal lymphatic vessel endothelial cell morphology ( J:181715 )

• in the presence of platelets, reduced migration of lymphatic endothelial cells in a transmigration assay is weaker compared to in the presence of control platelets

nervous system

intracranial hemorrhage ( J:181715 )

• brain hemorrhages at E12.5