Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkaa2tm1Vio mutation
(1 available);
any
Prkaa2 mutation
(33 available)
Tg(CAG-Tfb1m)AGsha mutation
(1 available)
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hearing/vestibular/ear
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N |
• ABR thresholds are similar to wild-type controls, indicating rescue or delay of the premature hearing loss seen in single Tg(CAG-Tfb1m)AGsha transgenic mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f1tm1Meg mutation
(2 available);
any
E2f1 mutation
(25 available)
Tg(CAG-Tfb1m)AGsha mutation
(1 available)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-Tfb1m)AGsha mutation
(1 available)
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hearing/vestibular/ear
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• 40% reduction in endocochlear potential in 9 to 12 month old mice
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• outer hair cells exhibit a positive shift of nearly 20 mV in the voltage at peak capacitance, indicating a mild impairment of voltage-dependent electromotility
• however, hair cells in the apex of the cochlea are intact
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• mice exhibit increased latency to peak I at 8 kHz of the ABR at 9-12 months of age but not at 3-6 months of age, indicating dysfunctional cochlear and/or nerve VIII processing only in older mice with hearing loss
• ABR peak I amplitudes are reduced in 9-12 month old mice
• however, central conduction time reflecting synaptic and nerve conduction timing after cochlear/nerve VIII processing is unchanged in mice with severe hearing loss
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• ABR thresholds are prematurely elevated
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• progressive hearing loss
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nervous system
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• outer hair cells exhibit a positive shift of nearly 20 mV in the voltage at peak capacitance, indicating a mild impairment of voltage-dependent electromotility
• however, hair cells in the apex of the cochlea are intact
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-Tfb1m)AGsha mutation
(1 available)
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Analysis Tools
