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Allele Symbol Allele Name Allele ID |
Odf2tm1.2Sats targeted mutation 1.2, Sachiko Tsukita MGI:5313543 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• gradual decrease in survival after birth with only 20% surviving beyond weaning
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• impaired
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• the number of cilia per single multiciliated tracheal cell is reduced
• however, cilia length is similar to wild-type controls
• in tracheal cilia some basal bodies fail to position apically and the basal foot is absent
• in tracheal cilia the rotational polarity of axonemes is scattered
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• the number of cilia per single multiciliated tracheal cell is reduced
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• coordinated tracheal ciliary beating is disturbed with the direction of beating dispersed rather than in the lung to oral direction seen in wild-type mice
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• in ex vivo bead assay the flow of fluorescent beads reveals only limited uncoordinated movement
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• display a coughing/sneezing like phenotype
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| N |
• unexpectedly mice are born with primary cilia
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• tendency toward a decrease in the number of cilia per cell in multiciliated cells in the oviduct and brain ventricle
• in cilia in the trachea, oviduct and brain ventricle basal feet are absent
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• in cilia basal feet are absent
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• tendency toward a decrease in the number of cilia per cell in multiciliated cells
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• about 30% shorter than in wild-type controls
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• tendency toward a decrease in the number of cilia per cell in multiciliated cells
• in cilia basal feet are absent
|
|
• the number of cilia per single multiciliated tracheal cell is reduced
• however, cilia length is similar to wild-type controls
• in tracheal cilia some basal bodies fail to position apically and the basal foot is absent
• in tracheal cilia the rotational polarity of axonemes is scattered
|
|
• the number of cilia per single multiciliated tracheal cell is reduced
|
|
• coordinated tracheal ciliary beating is disturbed with the direction of beating dispersed rather than in the lung to oral direction seen in wild-type mice
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• about 30% shorter than in wild-type controls
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• about 70 - 80% of wild-type littermates
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• tendency toward a decrease in the number of cilia per cell in multiciliated cells
• in cilia basal feet are absent
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• in cilia basal feet are absent
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• tendency toward a decrease in the number of cilia per cell in multiciliated cells
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• slight tendency for hydrocephaly
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| N |
• no increases in inflammation levels in the lung are detected in mice kept in specific pathogen free conditions
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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