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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tgfb3tm1Moaz
targeted mutation 1, Mohamad Azhar
MGI:5313415
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tgfb3tm1Moaz/Tgfb3tm1Moaz involves: 129S6/SvEvTac * Black Swiss * C57BL/6J MGI:5313417
cn2
 		Tgfb3tm1Moaz/Tgfb3tm1.1Moaz
Tg(EIIa-cre)C5379Lmgd/0 		involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * FVB/N MGI:5313418


Genotype
MGI:5313417
hm1
Allelic
Composition		 Tgfb3tm1Moaz/Tgfb3tm1Moaz
Genetic
Background		 involves: 129S6/SvEvTac * Black Swiss * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgfb3tm1Moaz mutation (1 available); any Tgfb3 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:181226 )
• mice are viable, fertile, and born at near the expected rtatio




Genotype
MGI:5313418
cn2
Allelic
Composition		 Tgfb3tm1Moaz/Tgfb3tm1.1Moaz
Tg(EIIa-cre)C5379Lmgd/0
Genetic
Background		 involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(EIIa-cre)C5379Lmgd mutation (4 available)
Tgfb3tm1.1Moaz mutation (0 available); any Tgfb3 mutation (34 available)
Tgfb3tm1Moaz mutation (1 available); any Tgfb3 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:181226 )
• although born at the expected ratio, homozyotes gasp, suckle poorly and die

respiratory system
respiratory distress ( J:181226 )
• gasping after birth

behavior/neurological
absent gastric milk in neonates ( J:181226 )
• little or no milk in pups' stomachs
abnormal suckling behavior ( J:181226 )
• suckle poorly

craniofacial
cleft palate ( J:181226 )
• complete or partial cleft palate in all E18.5 embryos and in new born pups

digestive/alimentary system
cleft palate ( J:181226 )
• complete or partial cleft palate in all E18.5 embryos and in new born pups

growth/size/body
cleft palate ( J:181226 )
• complete or partial cleft palate in all E18.5 embryos and in new born pups
complete cleft palate ( J:181226 )




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory