Phenotypes associated with this allele

• Allele Symbol: Mamstr^tm1.2Eno
• Allele Name: targeted mutation 1.2, Eric N Olson
• Allele ID: MGI:5313410
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mamstr^tm1.2Eno/Mamstr^tm1.2Eno	involves: 129 * C57BL/6	MGI:5313411
cx2	Mamstr^tm1.2Eno/Mamstr^tm1.2Eno Mrtfa^tm1Eno/Mrtfa^tm1Eno	involves: 129 * C57BL/6	MGI:5313413
cx3	Dmd^mdx/Dmd^mdx Mamstr^tm1.2Eno/Mamstr^tm1.2Eno	involves: 129 * C57BL/6 * C57BL/10ScSn	MGI:5313412

Genotype
MGI:5313411

hm1

• Allelic Composition: Mamstr^tm1.2Eno/Mamstr^tm1.2Eno
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

impaired skeletal muscle regeneration ( J:179880 )

• 7 days after cardiotoxin induced muscle damage myofibers show no centralized nuclei and instead are composed of degenerating necrotic fibers, fibrotic tissue, and inflammatory cells

• at 14 days post cardiotoxin injury myofibers remain heterogeneous in size and are fewer in number compared with wild-type muscle

• regeneration in response to BaCl2 injury is also impaired

Genotype
MGI:5313413

cx2

• Allelic Composition: Mamstr^tm1.2Eno/Mamstr^tm1.2Eno; Mrtfa^tm1Eno/Mrtfa^tm1Eno
• Genetic Background: involves: 129 * C57BL/6

mortality/aging

perinatal lethality, incomplete penetrance ( J:179880 )

• about 40% die perinatally

muscle

decreased skeletal muscle weight ( J:179880 )

• in mice that survive past P1

muscular atrophy ( J:179880 )

• dramatic muscle wasting at 44 weeks of age

abnormal muscle physiology ( J:179880 )

• failure of satellite cell differentiation

abnormal skeletal muscle satellite cell proliferation ( J:179880 )

• hyperproliferative in culture

impaired skeletal muscle regeneration ( J:179880 )

• complete absence of myofiber regeneration at 7 days post cardiotoxin induced muscle injury

cellular

abnormal skeletal muscle satellite cell proliferation ( J:179880 )

• hyperproliferative in culture

growth/size/body

decreased body weight ( J:179880 )

• in mice that survive past P1

cachexia ( J:179880 )

• dramatic muscle wasting at 44 weeks of age

Genotype
MGI:5313412

cx3

• Allelic Composition: Dmd^mdx/Dmd^mdx; Mamstr^tm1.2Eno/Mamstr^tm1.2Eno
• Genetic Background: involves: 129 * C57BL/6 * C57BL/10ScSn

muscle

abnormal skeletal muscle satellite cell proliferation ( J:179880 )

♀ • hyperproliferative in culture

decreased skeletal muscle weight ( J:179880 )

♀ • at 4 and 6 weeks of age compared to mice homozygous for Dmd^mdx alone

skeletal muscle fibrosis ( J:179880 )

♀ • severe muscle damage and increased fibrosis

muscle degeneration ( J:179880 )

♀ • severe muscle damage and increased fibrosis

growth/size/body

decreased body weight ( J:179880 )

♀ • at 4 and 6 weeks of age compared to mice homozygous for Dmd^mdx alone

cellular

abnormal skeletal muscle satellite cell proliferation ( J:179880 )

♀ • hyperproliferative in culture