Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dpysl2tm1.1Gosh mutation
(0 available);
any
Dpysl2 mutation
(34 available)
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nervous system
N |
• gross cytoarchitecture of the cortical layer is essentially normal
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• a slight but significant increase in the number of primary neurons displaying irregular curling dendritic elongation in culture
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crmp1tm1Pako mutation
(2 available);
any
Crmp1 mutation
(45 available)
Dpysl2tm1.1Gosh mutation
(0 available);
any
Dpysl2 mutation
(34 available)
Tg(Thy1-YFP)HJrs mutation
(3 available)
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nervous system
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• the basal dendrites of layer V pyramidal neurons grow to the apical side with curling and collaterals from apical trunks show disorientation and winding
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• the basal dendrites of layer V pyramidal neurons grow to the apical side with curling and collaterals from apical trunks show disorientation and winding
• cortical neurons show an increase in the number of primary dendrites
• the highest number of dendrite crossings is found at about 40 um compared to 60-80 um in controls
• the basal dendritic field is further shifted to the apical part of the cell body and to the close part of cell body compared to mutant mice wild-type for Crmp1
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crmp1tm1Pako mutation
(2 available);
any
Crmp1 mutation
(45 available)
Dpysl2tm1.1Gosh mutation
(0 available);
any
Dpysl2 mutation
(34 available)
|
|
|
nervous system
N |
• gross cytoarchitecture of the cortical layer is essentially normal
|
|
• significant increase in the number of primary neurons displaying irregular curling dendritic elongation in culture
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dpysl2tm1.1Gosh mutation
(0 available);
any
Dpysl2 mutation
(34 available)
Tg(Thy1-YFP)HJrs mutation
(3 available)
|
|
|
nervous system
|
• cortical neurons show an increase in the number of primary dendrites
• the basal dendritic field is slightly shifted to the apical side of the cell body
|