Analysis Tools
nervous system
| N |
• mice exhibit normal hippocampus morphology at 9-10 months of age
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• size of the readily releasable pool (RRP) of SVs is larger than that in wild-type controls
• SV density is significantly increased in excitatory hippocampal neurons, indicating that neurons with only nCLCa clathrin can compensate for defective SV regeneration by expanding their SV pool from another pathway
• other parameters, including individual SV size, postsynaptic density length and excitatory synapse density are similar to those in wild-type controls
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• in hippocampal neurons, the rate of synaptic vesicle (SV) recycling is decreased, indicating a defect in acute SV pool replenishment
• however, mice are able to support a compensatory pathway of SV formation
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• in hippocampal slices, the evoked excitatory postsynaptic current (EPSC) response amplitude is of comparable or higher magnitude than that in wild-type controls, suggesting that basal synaptic transmission is intact or even enhanced
• no differences in the paired-pulse ratio (PPR) are observed
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mortality/aging
| N |
• mice exhibit normal survival rates after weaning
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behavior/neurological
| N |
• mice exhibit normal motor coordination in an accelerating rotarod test
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