All Phenotypes Cd8a<tm2.1(Cd4)Asin> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cd8a^{tm2.1(Cd4)Asin}
targeted mutation 2.1, Alfred Singer
MGI:5309010

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	B2m^tm1Unc/B2m^tm1Unc Cd4^tm1Mak/Cd4^tm1Mak Cd8a^{tm2.1(Cd4)Asin}/Cd8a^{tm2.1(Cd4)Asin}	involves: 129 * C57BL/6	MGI:5309023

Allelic Composition	B2m^tm1Unc/B2m^tm1Unc Cd4^tm1Mak/Cd4^tm1Mak Cd8a^{tm2.1(Cd4)Asin}/Cd8a^{tm2.1(Cd4)Asin}
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2m^tm1Unc mutation (38 available); any B2m mutation (122 available)
Cd4^tm1Mak mutation (5 available); any Cd4 mutation (82 available)
Cd8a^{tm2.1(Cd4)Asin} mutation (1 available); any Cd8a mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell physiology ( J:180236 )

• lack of helper T cell function

• retain cytotoxic T cell functions

hematopoietic system

abnormal T cell physiology ( J:180236 )

• lack of helper T cell function

• retain cytotoxic T cell functions

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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