All Phenotypes Cd8a<tm2.1(Cd4)Asin> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cd8a^{tm2.1(Cd4)Asin}
targeted mutation 2.1, Alfred Singer
MGI:5309010

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	B2m^tm1Unc/B2m^tm1Unc Cd4^tm1Mak/Cd4^tm1Mak Cd8a^{tm2.1(Cd4)Asin}/Cd8a^{tm2.1(Cd4)Asin}	involves: 129 * C57BL/6	MGI:5309023

Allelic Composition	B2m^tm1Unc/B2m^tm1Unc Cd4^tm1Mak/Cd4^tm1Mak Cd8a^{tm2.1(Cd4)Asin}/Cd8a^{tm2.1(Cd4)Asin}
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2m^tm1Unc mutation (36 available); any B2m mutation (117 available)
Cd4^tm1Mak mutation (5 available); any Cd4 mutation (85 available)
Cd8a^{tm2.1(Cd4)Asin} mutation (1 available); any Cd8a mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell physiology ( J:180236 )

• lack of helper T cell function

• retain cytotoxic T cell functions

hematopoietic system

abnormal T cell physiology ( J:180236 )

• lack of helper T cell function

• retain cytotoxic T cell functions

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24