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Allele Symbol Allele Name Allele ID |
Cdx2tm2Fbe targeted mutation 2, F Beck MGI:5308966 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• cystic vesicles appear 1 week after treatment with tamoxifen and BNF, earlier than in mutant mice wild-type for Cdx1
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• cystic vesicles appear 1 week after treatment with tamoxifen and BNF, earlier than in mutant mice wild-type for Cdx1
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• by 6 weeks after treatment cystic vesicles persist and are often filled with mucous and detritus
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• an excess of Paneth cells are found by 19-62 weeks after treatment and these cells contain an abnormally abundant number of normal looking secretory granules
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• 4 weeks after treatment with tamoxifen a low level of excess mucous secretion is seen
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• by 6 weeks after treatment dying Paneth cells are commonly seen
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• recombined cells fail to migrate out of the crypts and up the villi in the intestine
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• by 6 weeks after treatment cystic vesicles persist and are often filled with mucous and detritus
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• an excess of Paneth cells are found by 19-62 weeks after treatment and these cells contain an abnormally abundant number of normal looking secretory granules
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 4 weeks after treatment with tamoxifen and BNF a bias towards the production of secretory cells is detected with an excess of mucous-secreting cells in the upper part of the crypts and towards the bases of the villi
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• 4 weeks after treatment with tamoxifen and BNF crypts become sealed off into cystic vesicles and display a severe degree of hypoproliferation
• by 6 weeks after treatment cystic vesicles persist and are often filled with mucous and detritus
• cystic vesicles continue to persist 19-62 weeks after treatment although the surface epithelium consists of unrecombined cells
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• abnormal and frequently moribund 4 weeks after treatment with tamoxifen and BNF
• an excess of Paneth cells are found by 19-62 weeks after treatment and these cells contain an abnormally abundant number of normal looking secretory granules
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• in some mice polyps containing large irregular vesicles develop after treatment with tamoxifen and BNF
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• by 6 weeks after treatment in isolated areas of the distal ileum recombined crypts have replaced the villi
• beyond 19 weeks these recombined regions develop into antral-like branched tubular glands secreting PASpositive, Alcian Blue-negative mucous
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• 4 weeks after treatment with tamoxifen and BNF villi are misshapen
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• 4 weeks after treatment with tamoxifen and beta-naphthoflavone (BNF) the gut becomes abnormally viscid
• by 6 weeks after treatment dying Paneth cells are commonly seen
|
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• by 6 weeks after treatment dying Paneth cells are commonly seen
|
|
• recombined cells fail to migrate out of the crypts and up the villi in the intestine
|
|
• 4 weeks after treatment with tamoxifen and BNF crypts become sealed off into cystic vesicles and display a severe degree of hypoproliferation
• by 6 weeks after treatment cystic vesicles persist and are often filled with mucous and detritus
• cystic vesicles continue to persist 19-62 weeks after treatment although the surface epithelium consists of unrecombined cells
|
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• abnormal and frequently moribund 4 weeks after treatment with tamoxifen and BNF
• an excess of Paneth cells are found by 19-62 weeks after treatment and these cells contain an abnormally abundant number of normal looking secretory granules
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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