Analysis Tools
mortality/aging
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• this strain is "maintained in an heterozygous state since homozygous mice are not viable"
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Allele Symbol Allele Name Allele ID |
Tg(Ins2-crmA)27Ngkh transgene insertion 27, Nicolas Glaichenhaus MGI:5308875 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• this strain is "maintained in an heterozygous state since homozygous mice are not viable"
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• after 60 hours' incubation of pancreatic islets from transgenic or wild-type NOD mice with interleukin 1 beta and interferon gamma, which induces surface expression of FAS, followed by exposure to soluble FAS ligand (FASL), the proportion of apoptotic beta cells increased from 13% (in the absence of FASL) to 32% in wild-type NOD islets but from 12% to only 17% in islets from transgenic mice
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• whereas treatment with a single injection of streptozotoxin protects wild-type NOD mice from spontaneous development of diabetes, transgenic NOD mice are not thus protected
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• although NOD mice with this transgene spontaneously develop diabetes with the same incidence and kinetics as their nontransgenic littermates, they are almost completely protected from trasference of diabetes by injection of splenocytes from spontaneously diabetic NOD mice following full-body irradiation
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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