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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mirc21tm1.1Lhe
targeted mutation 1.1, Lin He
MGI:5308794
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mirc21tm1.1Lhe/Mirc21tm1.1Lhe involves: 129S4/SvJae * C57BL/6 MGI:5308798
cx2
 		Mir34atm1.1Lhe/Mir34atm1.1Lhe
Mirc21tm1.1Lhe/Mirc21tm1.1Lhe 		involves: 129S4/SvJae * C57BL/6 * C57BL/6J MGI:5308800


Genotype
MGI:5308798
hm1
Allelic
Composition		 Mirc21tm1.1Lhe/Mirc21tm1.1Lhe
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc21tm1.1Lhe mutation (1 available); any Mirc21 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell physiology ( J:180692 )
• un-induced mouse embryonic fibroblasts exhibit an increase in reprogramming efficiency and generation of induced pluripotent stem cell compared with wild-type cells




Genotype
MGI:5308800
cx2
Allelic
Composition		 Mir34atm1.1Lhe/Mir34atm1.1Lhe
Mirc21tm1.1Lhe/Mirc21tm1.1Lhe
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir34atm1.1Lhe mutation (2 available); any Mir34a mutation (12 available)
Mirc21tm1.1Lhe mutation (1 available); any Mirc21 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
cellular phenotype ( J:180692 )
N
• induced pluripotent stem cells (iPSCs) resemble wild-type iPSCs
abnormal cell physiology ( J:180692 )
• un-induced mouse embryonic fibroblasts exhibit an increase in reprogramming efficiency and generation of iPSCs compared with wild-type and single homozygous cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory