All Phenotypes Mir34a<tm1.1Lhe> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mir34a^tm1.1Lhe
targeted mutation 1.1, Lin He
MGI:5308792

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir34a^tm1.1Lhe/Mir34a^tm1.1Lhe	involves: C57BL/6 * C57BL/6J	MGI:5308796
cx2	Cdkn1a^tm1Tyj/Cdkn1a^tm1Tyj Mir34a^tm1.1Lhe/Mir34a^tm1.1Lhe	involves: 129S2/SvPas * C57BL/6 * C57BL/6J	MGI:5308802
cx3	Mir34a^tm1.1Lhe/Mir34a^tm1.1Lhe Pou5f1^tm2Jae/Pou5f1⁺	involves: 129S4/SvJae * C57BL/6 * C57BL/6J	MGI:5308797
cx4	Mir34a^tm1.1Lhe/Mir34a^tm1.1Lhe Mirc21^tm1.1Lhe/Mirc21^tm1.1Lhe	involves: 129S4/SvJae * C57BL/6 * C57BL/6J	MGI:5308800

Allelic Composition	Mir34a^tm1.1Lhe/Mir34a^tm1.1Lhe
Genetic Background	involves: C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir34a^tm1.1Lhe mutation (1 available); any Mir34a mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

cellular phenotype ( J:180692 )

N	• mouse embryonic cells exhibit normal proliferation within the first 6 passages, apoptotic response, DNA damage response, induced pluripotent stem cell pluripotency (iPSCs) and senescence during reprogramming

abnormal cell physiology ( J:180692 )

• induced mouse embryonic fibroblasts exhibit an increase in reprogramming efficiency and generation of iPSCs compared with wild-type cells

Allelic Composition	Cdkn1a^tm1Tyj/Cdkn1a^tm1Tyj Mir34a^tm1.1Lhe/Mir34a^tm1.1Lhe
Genetic Background	involves: 129S2/SvPas * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1a^tm1Tyj mutation (3 available); any Cdkn1a mutation (60 available)
Mir34a^tm1.1Lhe mutation (1 available); any Mir34a mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell physiology ( J:180692 )

• induced mouse embryonic fibroblasts exhibit an increase in reprogramming efficiency and generation of induced pluripotent stem cell compared with wild-type and Mir34a^tm1.1Ghan cells

Allelic Composition	Mir34a^tm1.1Lhe/Mir34a^tm1.1Lhe Pou5f1^tm2Jae/Pou5f1⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir34a^tm1.1Lhe mutation (1 available); any Mir34a mutation (9 available)
Pou5f1^tm2Jae mutation (1 available); any Pou5f1 mutation (82 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell physiology ( J:180692 )

• induced mouse embryonic fibroblasts exhibit a greater than 4-fold increase in reprogramming efficiency and generation of induced pluripotent stem cell compared with wild-type and Mir34a^tm1.1Ghan cells

Allelic Composition	Mir34a^tm1.1Lhe/Mir34a^tm1.1Lhe Mirc21^tm1.1Lhe/Mirc21^tm1.1Lhe
Genetic Background	involves: 129S4/SvJae * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir34a^tm1.1Lhe mutation (1 available); any Mir34a mutation (9 available)
Mirc21^tm1.1Lhe mutation (1 available); any Mirc21 mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

cellular phenotype ( J:180692 )

N	• induced pluripotent stem cells (iPSCs) resemble wild-type iPSCs

abnormal cell physiology ( J:180692 )

• un-induced mouse embryonic fibroblasts exhibit an increase in reprogramming efficiency and generation of iPSCs compared with wild-type and single homozygous cells

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