Analysis Tools
mortality/aging
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• mice die during young adulthood
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growth/size/body
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Allele Symbol Allele Name Allele ID |
Pax7tm1.1(HBEGF,-EYFP)Mal targeted mutation 1.1, Bernard Malissen MGI:5308728 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die during young adulthood
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• diphtheria toxin-treated mice retain multipotent fibroblastic/adipogenic mesenchymal progenitors
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• diphtheria toxin-treated mice exhibit modest cellular interstitial infiltration (primarily macrophagic) in muscles unlike in similarly treated wild-type mice
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• in diphtheria-treated muscles, even following diphtheria toxin depletion
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• mice treated with diphtheria and cardiotoxin exhibit impaired muscle regeneration with massive tissue infiltration, loss of myofibres and failure to reconstitute skeletal muscle tissue structure and mass compared with similarly treated wild-type mice
• following treatment and depletion of diphtheria toxin, cardiotoxin-treated mice exhibit impaired muscle regeneration with inflammation and fat infiltration unlike wild-type mice
• diphtheria toxin treated mice subjected to an exercise routine exhibit a dramatic loss of myofibers, inflammation, fat infiltration, and loss of muscle mass unlike similarly treated wild-type mice
• transplantation of satellite cells expressing Tg(Pax7-EGFP)#Tajb fails to rescue muscle regeneration in diphtheria toxin-treated mice
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• diphtheria toxin-treated mice exhibit modest cellular interstitial infiltration (primarily macrophagic) in muscles unlike in similarly treated wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice treated with diphtheria toxin and cardiotoxin exhibit an almost total loss of GFP+ satellite cells
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• mice treated with diphtheria and cardiotoxin exhibit impaired muscle regeneration compared with similarly treated wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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