Phenotypes associated with this allele

• Allele Symbol: Esco2^tm1.2Ge
• Allele Name: targeted mutation 1.2, Gregor Eichele
• Allele ID: MGI:5308063
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Esco2^tm1.2Ge/Esco2^tm1.2Ge	involves: 129S2/SvPas * C57BL/6 * FVB/N * SJL	MGI:5308069

Genotype
MGI:5308069

hm1

• Allelic Composition: Esco2^tm1.2Ge/Esco2^tm1.2Ge
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:180371 )

• as early as 8-cell stage

embryo

abnormal preimplantation embryo development ( J:180371 )

• at the second cell division cells exhibit numerous lagging chromosomes randomly scattered between the two pole-ward-moving chromosome masses

• chromosomes exhibit cohesion defects at the centromere

cellular

abnormal mitosis ( J:180371 )

• at the second cell division cells exhibit numerous lagging chromosomes randomly scattered between the two pole-ward-moving chromosome masses

• chromosomes exhibit cohesion defects at the centromere