Analysis Tools
mortality/aging
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• most mice die around P20 for unknown reasons
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nervous system
| N |
• mice exhibit normal granule and cone cell proliferation
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• at P6 in the dentate gyrus and cortex
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• at P6
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• at P6 and 2 months of age, but not P1
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• dentate granule cells exhibit aberrant outgrowth of mossy fibers into CA3 compared with wild-type cells
• however, transfection of retina with an adenovirus expressing a short-hairpin RNA targeting Lhx2 rescues dentate gyrus axon phenotype
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• mislocalized
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• mice exhibit a reduction in cone cells compared with wild-type mice
• however, transfection of retina with an adenovirus expressing a short-hairpin RNA targeting Lhx2 rescues cone cell reduction
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vision/eye
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• at P3
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• mislocalized
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• mice exhibit a reduction in cone cells compared with wild-type mice
• however, transfection of retina with an adenovirus expressing a short-hairpin RNA targeting Lhx2 rescues cone cell reduction
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• reduced amplitude
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behavior/neurological
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• at 4 and 5 months of age
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cellular
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• at P6 in the dentate gyrus and cortex
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• at P3
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