Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir124a-1hgtm1Tfur mutation
(2 available);
any
Mir124a-1hg mutation
(3 available)
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nervous system
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• aberrant outgrowth of mossy fibers
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir124a-1hgtm1Tfur mutation
(2 available);
any
Mir124a-1hg mutation
(3 available)
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mortality/aging
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• most mice die around P20 for unknown reasons
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nervous system
N |
• mice exhibit normal granule and cone cell proliferation
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• at P6 in the dentate gyrus and cortex
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• at P6 and 2 months of age, but not P1
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• dentate granule cells exhibit aberrant outgrowth of mossy fibers into CA3 compared with wild-type cells
• however, transfection of retina with an adenovirus expressing a short-hairpin RNA targeting Lhx2 rescues dentate gyrus axon phenotype
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• mice exhibit a reduction in cone cells compared with wild-type mice
• however, transfection of retina with an adenovirus expressing a short-hairpin RNA targeting Lhx2 rescues cone cell reduction
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vision/eye
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• mice exhibit a reduction in cone cells compared with wild-type mice
• however, transfection of retina with an adenovirus expressing a short-hairpin RNA targeting Lhx2 rescues cone cell reduction
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behavior/neurological
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• at 4 and 5 months of age
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cellular
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• at P6 in the dentate gyrus and cortex
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir124a-1hgtm1Tfur mutation
(2 available);
any
Mir124a-1hg mutation
(3 available)
Mir124a-2tm1.1Tfur mutation
(1 available);
any
Mir124a-2 mutation
(3 available)
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nervous system
growth/size/body
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir124a-1hgtm1Tfur mutation
(2 available);
any
Mir124a-1hg mutation
(3 available)
Mir124a-2tm1.1Tfur mutation
(1 available);
any
Mir124a-2 mutation
(3 available)
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mortality/aging
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• no mice are produced from heterozygotes
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growth/size/body
nervous system
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir124a-1hgtm1Tfur mutation
(2 available);
any
Mir124a-1hg mutation
(3 available)
Tg(Crx-DsRed,-Mir124a-2)#Tfur mutation
(0 available)
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vision/eye
N |
• reduction and mislocalization of cone cells observed in A930011O12Rik/Mir124a-1tm1Tfur homozygotes is rescued
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir124a-1hgtm1Tfur mutation
(2 available);
any
Mir124a-1hg mutation
(3 available)
Tg(Syn1-DsRed,-Mir124a-2)#Tfur mutation
(0 available)
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nervous system
N |
• apoptosis in the dentate gyrus observed in A930011O12Rik/Mir124a-1tm1Tfur homozygotes is rescued
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