Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Card11tm1.1Litt mutation
(0 available);
any
Card11 mutation
(58 available)
Gt(ROSA)26Sortm1(cre/ERT2)Thl mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(TcraTcrb)425Cbn mutation
(3 available)
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immune system
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• reactivation is prevented after in vitro activation with Ova and tamoxifen treatment
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hematopoietic system
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• reactivation is prevented after in vitro activation with Ova and tamoxifen treatment
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Card11tm1.1Litt mutation
(0 available);
any
Card11 mutation
(58 available)
Tnfrsf4tm2(cre)Nik mutation
(1 available);
any
Tnfrsf4 mutation
(33 available)
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immune system
N |
• memory T cell development is unaffected
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• impaired "reactivation" of T cells after a second antibody challenge
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• decreased cellular infiltration of lungs when rechallenged 6 weeks after initial Ova exposure
• fewer cells in bronchoalveolar lavage fluid
• fewer eosinophiles
• increased number of macrophage
• reduced number of activated T cells after rechallenge (CD4+CD69+)
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respiratory system
N |
• acute airway response to Ova challenge is unaffected
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• decreased cellular infiltration of lungs when rechallenged 6 weeks after initial Ova exposure
• fewer cells in bronchoalveolar lavage fluid
• fewer eosinophiles
• increased number of macrophage
• reduced number of activated T cells after rechallenge (CD4+CD69+)
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hematopoietic system
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• impaired "reactivation" of T cells after a second antibody challenge
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