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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cbx8tm1Hko
targeted mutation 1, Haruhiko Koseki
MGI:5306629
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cbx8tm1Hko/Cbx8tm1Hko
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+ 		involves: 129 * C57BL/6 * C57BL/6NTac MGI:5306649


Genotype
MGI:5306649
cn1
Allelic
Composition		 Cbx8tm1Hko/Cbx8tm1Hko
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbx8tm1Hko mutation (1 available); any Cbx8 mutation (17 available)
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (2 available); any Gt(ROSA)26Sor mutation (944 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell physiology ( J:178955 )
• MigR1-MLL-AF9-transformed and tamoxifen-treated bone marrow cells exhibit impaired initiation and maintenance of leukemic transformation

hematopoietic system
hematopoietic system phenotype ( J:178955 )
N
• tamoxifen-treated mice exhibit normal hematopoiesis, long-term hematopoietic stem cell maintenance, and stem and progenitor cell function




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory