Phenotypes associated with this allele

• Allele Symbol: Slc24a4^tm1.1Hazh
• Allele Name: targeted mutation 1.1, Haiqing Zhao
• Allele ID: MGI:5306364
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc24a4^tm1.1Hazh/Slc24a4^tm1.1Hazh	involves: 129S6/SvEvTac	MGI:5551482
hm2	Slc24a4^tm1.1Hazh/Slc24a4^tm1.1Hazh	involves: 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:5306366

Genotype
MGI:5551482

hm1

• Allelic Composition: Slc24a4^tm1.1Hazh/Slc24a4^tm1.1Hazh
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal enamel morphology ( J:202571 )

• 6 month old mice show gross enamel defects and exhibit failed enamel mineralization

abnormal enamel mineralization ( J:202571 )

• failed enamel mineralization

skeleton

abnormal enamel morphology ( J:202571 )

• 6 month old mice show gross enamel defects and exhibit failed enamel mineralization

abnormal enamel mineralization ( J:202571 )

• failed enamel mineralization

growth/size/body

abnormal enamel morphology ( J:202571 )

• 6 month old mice show gross enamel defects and exhibit failed enamel mineralization

abnormal enamel mineralization ( J:202571 )

• failed enamel mineralization

Genotype
MGI:5306366

hm2

• Allelic Composition: Slc24a4^tm1.1Hazh/Slc24a4^tm1.1Hazh
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

taste/olfaction

abnormal olfactory system physiology ( J:180325 )

• olfactory sensory neurons exhibit slowed response termination, over-adapt to repeated odorant exposure, and fire fewer action potentials when adapted compared with wild-type cells

abnormal odor adaptation ( J:180325 )

• olfactory sensory neurons exhibit over-adapt to repeated odorant exposure and fire fewer action potentials when adapted compared with wild-type cells

impaired olfaction ( J:180325 )

• mice exhibit reduced ability to locate odors, as indicated by postnatal decreased body weight, compared with normal mice

nervous system

abnormal sensory neuron physiology ( J:180325 )

• olfactory sensory neurons exhibit slowed response termination, over-adapt to repeated odorant exposure, and fire fewer action potentials when adapted compared with wild-type cells

growth/size/body

decreased body weight ( J:180325 )

• likely due to impaired olfaction

• however, weight difference is less pronounced after weaning