All Phenotypes Apc<tm1.1Alew> MGI Mouse

neoplasm

• mice exhibit increased incidents and polyp size with more frequent paneth cell differentiation and polyp crypt fission with normal tissue compared with Apc^Min heterozygotes

increased adenoma incidence ( J:180057 )

• gastric and intestinal

increased intestinal adenoma incidence ( J:180057 , J:180275 )

• however, no carcinomas are observed (J:180057)

• adenoma gastrointestinal polyps, greatest in the small intestine (J:180275)

digestive/alimentary system

gastrointestinal tract polyps ( J:180057 , J:180275 )

• adenoma gastrointestinal polyps, greatest in the small intestine (J:180275)

• severe polyposis with increased incidents and polyp size compared with Apc^Min heterozygotes (J:180275)

increased intestinal adenoma incidence ( J:180057 , J:180275 )

• however, no carcinomas are observed (J:180057)

• adenoma gastrointestinal polyps, greatest in the small intestine (J:180275)

cellular

increased apoptosis ( J:180275 )

• in polyps

increased cell proliferation ( J:180275 )

• in polyps

hematopoietic system

anemia ( J:180275 )

• mice are euthanized by 12 weeks of age due to symptoms of anemia

mortality/aging

premature death ( J:180275 )

• mice are euthanized by 12 weeks of age due to symptoms of anemia

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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