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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ightm1Ktom
targeted mutation 1, Kazuma Tomizuka
MGI:5305473
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ightm1Ktom/Ightm1Ktom involves: ICR MGI:5305485
cx2
 		Ightm1Ktom/Ightm1Ktom
Igktm1Ktom/Igktm1Ktom
Tc(HSA14)SC20Ktom/0
Tc(HSA2)W23Ktom/0 		involves: C57BL/6NCrlj * CBA/JNCrlj * ICR MGI:5305486
cx3
 		Ightm1Ktom/Ightm1Ktom
Tc(HSA2)W23Ktom/0 		involves: C57BL/6NCrlj * CBA/JNCrlj * ICR MGI:5305487


Genotype
MGI:5305485
hm1
Allelic
Composition		 Ightm1Ktom/Ightm1Ktom
Genetic
Background		 involves: ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm1Ktom mutation (0 available); any Igh mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell physiology ( J:59894 )
• mice lack functional B cells and immunoglobulin production is absent
abnormal immunoglobulin level ( J:178635 )
• immunoglobulins are absent

hematopoietic system
abnormal B cell physiology ( J:59894 )
• mice lack functional B cells and immunoglobulin production is absent
abnormal immunoglobulin level ( J:178635 )
• immunoglobulins are absent




Genotype
MGI:5305486
cx2
Allelic
Composition		 Ightm1Ktom/Ightm1Ktom
Igktm1Ktom/Igktm1Ktom
Tc(HSA14)SC20Ktom/0
Tc(HSA2)W23Ktom/0
Genetic
Background		 involves: C57BL/6NCrlj * CBA/JNCrlj * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm1Ktom mutation (0 available); any Igh mutation (45 available)
Igktm1Ktom mutation (0 available); any Igk mutation (31 available)
Tc(HSA14)SC20Ktom mutation (0 available); any Tc(HSA14)SC20Ktom mutation (0 available)
Tc(HSA2)W23Ktom mutation (0 available); any Tc(HSA2)W23Ktom mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell physiology ( J:59894 )
• mice express human immunoglobulins
• however, B cell development is normal

hematopoietic system
abnormal B cell physiology ( J:59894 )
• mice express human immunoglobulins
• however, B cell development is normal




Genotype
MGI:5305487
cx3
Allelic
Composition		 Ightm1Ktom/Ightm1Ktom
Tc(HSA2)W23Ktom/0
Genetic
Background		 involves: C57BL/6NCrlj * CBA/JNCrlj * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm1Ktom mutation (0 available); any Igh mutation (45 available)
Tc(HSA2)W23Ktom mutation (0 available); any Tc(HSA2)W23Ktom mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell physiology ( J:59894 )
• B cells exhibit expression of human IGH locus
• however, mice exhibit restored B cell development

hematopoietic system
abnormal B cell physiology ( J:59894 )
• B cells exhibit expression of human IGH locus
• however, mice exhibit restored B cell development




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory