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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Irak1tm1.1Pcoh
targeted mutation 1.1, Philip Cohen
MGI:5305277
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Irak1tm1.1Pcoh/Irak1tm1.1Pcoh involves: 129P2/OlaHsd * C57BL/6 MGI:5305283
cx2
 		Irak1tm1.1Pcoh/?
Irak2tm1.1Pcoh/? 		involves: 129P2/OlaHsd * C57BL/6 MGI:5548134
ot3
 		Irak1tm1.1Pcoh/Y involves: 129P2/OlaHsd * C57BL/6 MGI:5305284
ot4
 		Irak1tm1.1Pcoh/? involves: 129P2/OlaHsd MGI:5548132


Genotype
MGI:5305283
hm1
Allelic
Composition		 Irak1tm1.1Pcoh/Irak1tm1.1Pcoh
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irak1tm1.1Pcoh mutation (0 available); any Irak1 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:179219 )
• mice are born at normal Mendelian frequencies, are of normal size and weight, and did not spontaneously develop any obvious phenotype




Genotype
MGI:5548134
cx2
Allelic
Composition		 Irak1tm1.1Pcoh/?
Irak2tm1.1Pcoh/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irak1tm1.1Pcoh mutation (0 available); any Irak1 mutation (16 available)
Irak2tm1.1Pcoh mutation (0 available); any Irak2 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interferon-alpha secretion ( J:205798 )
• from plasmacytoid dendritic cell stimulated with CpG-B, CpG-A or the TLR7 agonist poly(dU)




Genotype
MGI:5305284
ot3
Allelic
Composition		 Irak1tm1.1Pcoh/Y
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irak1tm1.1Pcoh mutation (0 available); any Irak1 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:179219 )
• mice are born at normal Mendelian frequencies, are of normal size and weight, and did not spontaneously develop any obvious phenotype




Genotype
MGI:5548132
ot4
Allelic
Composition		 Irak1tm1.1Pcoh/?
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irak1tm1.1Pcoh mutation (0 available); any Irak1 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:205798 )
N
• bone marrow-derived macrophage exhibit normal cytokine production
decreased interferon-alpha secretion ( J:205798 )
• from plasmacytoid dendritic cell stimulated with CpG-A or the TLR7 agonist poly(dU)




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory