All Phenotypes Irak1<tm1.1Pcoh> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Irak1^tm1.1Pcoh
targeted mutation 1.1, Philip Cohen
MGI:5305277

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Irak1^tm1.1Pcoh/Irak1^tm1.1Pcoh	involves: 129P2/OlaHsd * C57BL/6	MGI:5305283
cx2	Irak1^tm1.1Pcoh/? Irak2^tm1.1Pcoh/?	involves: 129P2/OlaHsd * C57BL/6	MGI:5548134
ot3	Irak1^tm1.1Pcoh/Y	involves: 129P2/OlaHsd * C57BL/6	MGI:5305284
ot4	Irak1^tm1.1Pcoh/?	involves: 129P2/OlaHsd	MGI:5548132

Allelic Composition	Irak1^tm1.1Pcoh/Irak1^tm1.1Pcoh
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irak1^tm1.1Pcoh mutation (0 available); any Irak1 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:179219 )

• mice are born at normal Mendelian frequencies, are of normal size and weight, and did not spontaneously develop any obvious phenotype

Allelic Composition	Irak1^tm1.1Pcoh/? Irak2^tm1.1Pcoh/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irak1^tm1.1Pcoh mutation (0 available); any Irak1 mutation (16 available)
Irak2^tm1.1Pcoh mutation (0 available); any Irak2 mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased interferon-alpha secretion ( J:205798 )

• from plasmacytoid dendritic cell stimulated with CpG-B, CpG-A or the TLR7 agonist poly(dU)

Allelic Composition	Irak1^tm1.1Pcoh/Y
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irak1^tm1.1Pcoh mutation (0 available); any Irak1 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:179219 )

• mice are born at normal Mendelian frequencies, are of normal size and weight, and did not spontaneously develop any obvious phenotype

Allelic Composition	Irak1^tm1.1Pcoh/?
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irak1^tm1.1Pcoh mutation (0 available); any Irak1 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:205798 )

N	• bone marrow-derived macrophage exhibit normal cytokine production

decreased interferon-alpha secretion ( J:205798 )

• from plasmacytoid dendritic cell stimulated with CpG-A or the TLR7 agonist poly(dU)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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