Phenotypes associated with this allele

• Allele Symbol: Ncor1^tm1.1Ics
• Allele Name: targeted mutation 1.1, Mouse Clinical Institute
• Allele ID: MGI:5305235
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ncor1^tm1.1Ics/Ncor1^tm1.1Ics	involves: 129 * C57BL/6J	MGI:5575516
cn2	Ncor1^tm1.1Ics/Ncor1^tm1.1Ics Tg(ACTA1-cre)79Jme/0	involves: 129 * C57BL/6 * C57BL/6J * SJL	MGI:5305236

Genotype
MGI:5575516

cn1

• Allelic Composition: Ncor1^tm1.1Ics/Ncor1^tm1.1Ics
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

decreased liver glycogen level ( J:206152 )

hepatic steatosis ( J:206152 )

• ectopic accumulation of lipid in the liver

homeostasis/metabolism

decreased liver glycogen level ( J:206152 )

Genotype
MGI:5305236

cn2

• Allelic Composition: Ncor1^tm1.1Ics/Ncor1^tm1.1Ics; Tg(ACTA1-cre)79Jme/0
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

muscle

abnormal skeletal muscle morphology ( J:178827 )

• connective tissue between muscle bundles is less abundant

• increased mitochondrial content with more abundant and larger mitochondria

abnormal skeletal muscle fiber mitochondrial morphology ( J:178827 )

• increase in the number and size of mitochondria in skeletal muscle

abnormal quadriceps morphology ( J:178827 )

• decrease in the number of the more glycolytic MyHC2b fibers and an increase in the number of more oxidative MyHC2x and 2a fibers

abnormal gastrocnemius morphology ( J:178827 )

• large sections with reddish color

• decrease in the number of the more glycolytic MyHC2b fibers and an increase in the number of more oxidative MyHC2x and 2a fibers

abnormal soleus morphology ( J:178827 )

• more intensely red

increased skeletal muscle fiber diameter ( J:178827 )

abnormal muscle physiology ( J:178827 )

• increase in mitochondrial activity in the gastrocnemius

homeostasis/metabolism

decreased susceptibility to induced hypothermia ( J:178827 )

• more cold tolerant

decreased circulating cholesterol level ( J:178827 )

• in mice on a high fat diet

decreased circulating HDL cholesterol level ( J:178827 )

• in mice on a high fat diet

decreased circulating LDL cholesterol level ( J:178827 )

• in mice on a chow or high fat diet

abnormal gas homeostasis ( J:178827 )

increased oxygen consumption ( J:178827 )

• increased on both a high fat and chow diet

decreased respiratory quotient ( J:178827 )

• marked decrease in mice on a high fat diet

abnormal aerobic fitness ( J:178827 )

• increase in the VO2 values during exercise and slight increase in the maximal ability to utilize oxygen during exercise in mice on both a chow and high fat diet

enhanced exercise endurance ( J:178827 )

• run for a longer time and greater distance before exhaustion

behavior/neurological

increased locomotor activity ( J:178827 )

• total locomotor activity is increased

cellular

abnormal skeletal muscle fiber mitochondrial morphology ( J:178827 )

• increase in the number and size of mitochondria in skeletal muscle

limbs/digits/tail

abnormal quadriceps morphology ( J:178827 )

• decrease in the number of the more glycolytic MyHC2b fibers and an increase in the number of more oxidative MyHC2x and 2a fibers

abnormal gastrocnemius morphology ( J:178827 )

• large sections with reddish color

• decrease in the number of the more glycolytic MyHC2b fibers and an increase in the number of more oxidative MyHC2x and 2a fibers

abnormal soleus morphology ( J:178827 )

• more intensely red