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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Smad2tm1Xya
targeted mutation 1, Xiao Yang
MGI:5305134
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Smad2tm1Xya/Smad2tm1Xya
Tg(KRT5-cre)1Xya/0 		involves: 129S6/SvEvTac MGI:5305135
cn2
 		Ppm1atm1.1Xya/Ppm1atm1.1Xya
Smad2tm1Xya/Smad2tm1Xya
Tg(KRT5-cre)1Xya/0 		involves: 129S6/SvEvTac * FVB/N MGI:5305136


Genotype
MGI:5305135
cn1
Allelic
Composition		 Smad2tm1Xya/Smad2tm1Xya
Tg(KRT5-cre)1Xya/0
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad2tm1Xya mutation (0 available); any Smad2 mutation (52 available)
Tg(KRT5-cre)1Xya mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Accelerated re-epithelialization during wound healing in Smad2tm1Xya/Smad2tm1Xya Tg(KRT5-cre)1Xya/0 mice

homeostasis/metabolism
abnormal wound healing ( J:178733 )
• mice exhibit accelerated re-epithelialization and enhanced keratinocyte migration in wound healing compared with control mice

integument
increased keratinocyte migration ( J:178733 )
• during wound healing, keratinocyte migration is increased compared to in control mice

cellular
increased keratinocyte migration ( J:178733 )
• during wound healing, keratinocyte migration is increased compared to in control mice




Genotype
MGI:5305136
cn2
Allelic
Composition		 Ppm1atm1.1Xya/Ppm1atm1.1Xya
Smad2tm1Xya/Smad2tm1Xya
Tg(KRT5-cre)1Xya/0
Genetic
Background		 involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppm1atm1.1Xya mutation (0 available); any Ppm1a mutation (23 available)
Smad2tm1Xya mutation (0 available); any Smad2 mutation (52 available)
Tg(KRT5-cre)1Xya mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Re-epithelialization rate is accelerated in Smad2tm1Xya/Smad2tm1Xya Ppm1atm1.1Xya/Ppm1atm1.1Xya Tg(KRT5-cre)1Xya/0 mice

homeostasis/metabolism
abnormal wound healing ( J:178733 )
• mice exhibit accelerated re-epithelialization and enhanced keratinocyte migration in wound healing compared with control mice

integument
increased keratinocyte migration ( J:178733 )
• during wound healing, keratinocyte migration is increased compared to control mice

cellular
increased keratinocyte migration ( J:178733 )
• during wound healing, keratinocyte migration is increased compared to control mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory