Phenotypes associated with this allele

• Allele Symbol: Insc^tm1Jakn
• Allele Name: targeted mutation 1, Juergen A Knoblich
• Allele ID: MGI:5304348
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Insc^tm1Jakn/Insc^tm1Jakn Tg(Nes-cre)1Wmz/0	involves: C57BL/6	MGI:5304353

Genotype
MGI:5304353

cn1

• Allelic Composition: Insc^tm1Jakn/Insc^tm1Jakn; Tg(Nes-cre)1Wmz/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuronal precursor proliferation ( J:178712 )

• in the ventricular zone the number of basally located mitotic cells is strongly reduced at E14.5

abnormal brain development ( J:178712 )

abnormal cortical intermediate zone morphology ( J:178712 )

• thickness is reduced by about 25%

thin cortical plate ( J:178712 )

• thickness is reduced by about 40%

decreased brain size ( J:178712 )

• at E14.5

enlarged lateral ventricles ( J:178712 )

• at E14.5

abnormal cerebral cortex morphology ( J:178712 )

abnormal stratification in cerebral cortex ( J:178712 )

• fewer cells are present in layers II-IV

thin cerebral cortex ( J:178712 )

• cortical thickness is reduced by around 20% both medially and laterally

abnormal lateral ganglionic eminence morphology ( J:178712 )

• at E14.5 the protrusion of the lateral ganglionic eminence into the ventricles is reduced

abnormal neuron morphology ( J:178712 )

• the size of neurons in the cortical intermediate zone and cortical plate is reduced

decreased neuron number ( J:178712 )

• at E14.5 the number of cortical plate neurons is reduced by almost half

cellular

abnormal neuronal precursor proliferation ( J:178712 )

• in the ventricular zone the number of basally located mitotic cells is strongly reduced at E14.5