Phenotypes associated with this allele

• Allele Symbol: Mecp2^tm1.1Meg
• Allele Name: targeted mutation 1.1, Michael E Greenberg
• Allele ID: MGI:5302542
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mecp2^tm1.1Meg/Mecp2^tm1.1Meg	B6.129-Mecp2^tm1.1Meg	MGI:5302547
ot2	Mecp2^tm1.1Meg/Y	B6.129-Mecp2^tm1.1Meg	MGI:5302546

Genotype
MGI:5302547

hm1

• Allelic Composition: Mecp2^tm1.1Meg/Mecp2^tm1.1Meg
• Genetic Background: B6.129-Mecp2^tm1.1Meg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:178533 )

♀N • female mice are fertile

Genotype
MGI:5302546

ot2

• Allelic Composition: Mecp2^tm1.1Meg/Y
• Genetic Background: B6.129-Mecp2^tm1.1Meg

reproductive system

reproductive system phenotype ( J:178533 )

♂N • male mice are fertile

behavior/neurological

behavior/neurological phenotype ( J:178533 )

♂N • mice exhibit normal anxiety-related and motor behaviors, social approach, and spatial learning and memory

abnormal response to novelty ( J:178533 )

♂ • mice spend equal time investigating a novel objects or mouse as a familiar object or mouse unlike wild-type mice

abnormal response to novel object ( J:178533 )

♂ • mice spend equal time investigating a novel objects as a familiar object unlike wild-type mice

nervous system

abnormal dendrite morphology ( J:178533 )

♂ • cultured cortical neurons exhibit an increase in the average number of dendritic branches and increased dendritic complexity compared with wild-type cells

increased miniature inhibitory postsynaptic current amplitude ( J:178533 )

♂ • increased amplitude