All Phenotypes Rc3h1<tm1.2Mass> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rc3h1^tm1.2Mass
targeted mutation 1.2, Marc Schmidt-Supprian
MGI:5301574

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rc3h1^tm1.2Mass/Rc3h1^tm1.2Mass	involves: C57BL/6 * CBA * CD-1 * NZB * SJL	MGI:5301606
hm2	Rc3h1^tm1.2Mass/Rc3h1^tm1.2Mass	involves: C57BL/6 * CBA * NZB * SJL	MGI:5301605

Allelic Composition	Rc3h1^tm1.2Mass/Rc3h1^tm1.2Mass
Genetic Background	involves: C57BL/6 * CBA * CD-1 * NZB * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rc3h1^tm1.2Mass mutation (0 available); any Rc3h1 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Growth retardation and increased spleen size in Rc3h1^tm1.2Mass/Rc3h1^tm1.2Mass mice

mortality/aging

preweaning lethality, incomplete penetrance ( J:177784 )

• few mice survive to adulthood

immune system

immune system phenotype ( J:177784 )

N	• mice exhibit normal spontaneous germinal center formation, autoantibody production, and autoimmunity

enlarged spleen ( J:177784 )

increased spleen weight ( J:177784 )

abnormal effector T cell morphology ( J:177784 )

• mice exhibit an increase in CD8 effector-like T cells in the spleen compared with control mice

limbs/digits/tail

curly tail ( J:177784 )

• at birth and sometimes corrected later on

hematopoietic system

enlarged spleen ( J:177784 )

increased spleen weight ( J:177784 )

abnormal effector T cell morphology ( J:177784 )

• mice exhibit an increase in CD8 effector-like T cells in the spleen compared with control mice

growth/size/body

decreased body weight ( J:177784 )

postnatal growth retardation ( J:177784 )

enlarged spleen ( J:177784 )

increased spleen weight ( J:177784 )

Allelic Composition	Rc3h1^tm1.2Mass/Rc3h1^tm1.2Mass
Genetic Background	involves: C57BL/6 * CBA * NZB * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rc3h1^tm1.2Mass mutation (0 available); any Rc3h1 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Curly tail, skin, soft tissue and bone defect, and alveoli that are not properly expanded in Rc3h1^tm1.2Mass/Rc3h1^tm1.2Mass mice

mortality/aging

neonatal lethality, complete penetrance ( J:177784 )

• mice die within 6 hours of birth

skeleton

abnormal vertebral column morphology ( J:177784 )

• caudal spinal column malformations

respiratory system

primary atelectasis ( J:177784 )

immune system

abnormal thymus development ( J:177784 )

• embryonic thymus transplanted into athymic C57BL/6 nude mice exhibit atrophy without affecting T cell selection compared with mice transplanted with wild-type thymus

limbs/digits/tail

curly tail ( J:177784 )

hematopoietic system

abnormal thymus development ( J:177784 )

• embryonic thymus transplanted into athymic C57BL/6 nude mice exhibit atrophy without affecting T cell selection compared with mice transplanted with wild-type thymus

endocrine/exocrine glands

abnormal thymus development ( J:177784 )

• embryonic thymus transplanted into athymic C57BL/6 nude mice exhibit atrophy without affecting T cell selection compared with mice transplanted with wild-type thymus

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23