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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		S1pr4tm1Lipp
targeted mutation 1, Martin Lipp
MGI:5301363
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		S1pr4tm1Lipp/S1pr4tm1Lipp involves: 129X1/SvJ * C57BL/6J MGI:5301367


Genotype
MGI:5301367
hm1
Allelic
Composition		 S1pr4tm1Lipp/S1pr4tm1Lipp
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
S1pr4tm1Lipp mutation (0 available); any S1pr4 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:179199 )
N
• platelet number and bleed time are normal
abnormal thrombopoiesis ( J:179199 )
• following experimental thrombocytopenia, platelet repopulation is impaired compared to in similarly treated wild-type mice
• proplatelet formation in vitro is impaired compared with wild-type cells
abnormal megakaryocyte morphology ( J:179199 )
• some megakaryocytes have nongrained cytoplasm with numerous vacuoles unlike in wild-type mice

immune system
abnormal thrombopoiesis ( J:179199 )
• following experimental thrombocytopenia, platelet repopulation is impaired compared to in similarly treated wild-type mice
• proplatelet formation in vitro is impaired compared with wild-type cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory