Phenotypes associated with this allele

• Allele Symbol: B9d1^{tm1d(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1d, Wellcome Trust Sanger Institute
• Allele ID: MGI:5301332
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	B9d1^tm1d(EUCOMM)Wtsi/B9d1^tm1d(EUCOMM)Wtsi	involves: C57BL/6 * FVB/N * SJL	MGI:5301337
hm2	B9d1^tm1d(EUCOMM)Wtsi/B9d1^tm1d(EUCOMM)Wtsi	involves: C57BL/6N	MGI:5301843

Genotype
MGI:5301337

hm1

• Allelic Composition: B9d1^{tm1d(EUCOMM)Wtsi}/B9d1^{tm1d(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:178421 )

• authors state that mice exhibit phenotypes indistinguishable from B9d1^{tm1a(EUCOMM)Wtsi} homozygotes

cardiovascular system

abnormal cardiovascular system morphology ( J:178421 )

• authors state that mice exhibit phenotypes indistinguishable from B9d1^{tm1a(EUCOMM)Wtsi} homozygotes

craniofacial

abnormal craniofacial morphology ( J:178421 )

• authors state that mice exhibit phenotypes indistinguishable from B9d1^{tm1a(EUCOMM)Wtsi} homozygotes

embryo

abnormal embryo development ( J:178421 )

• authors state that mice exhibit phenotypes indistinguishable from B9d1^{tm1a(EUCOMM)Wtsi} homozygotes

limbs/digits/tail

abnormal limb morphology ( J:178421 )

• authors state that mice exhibit phenotypes indistinguishable from B9d1^{tm1a(EUCOMM)Wtsi} homozygotes

liver/biliary system

abnormal hepatobiliary system morphology ( J:178421 )

• authors state that mice exhibit phenotypes indistinguishable from B9d1^{tm1a(EUCOMM)Wtsi} homozygotes

renal/urinary system

abnormal kidney morphology ( J:178421 )

• authors state that mice exhibit phenotypes indistinguishable from B9d1^{tm1a(EUCOMM)Wtsi} homozygotes

Genotype
MGI:5301843

hm2

• Allelic Composition: B9d1^{tm1d(EUCOMM)Wtsi}/B9d1^{tm1d(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6N

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:178978 )

• die around E15.5

embryo

abnormal embryonic neuroepithelium morphology ( J:178978 )

• striking loss of cilia in the spinal cord neuroectoderm

nervous system

abnormal nervous system development ( J:178978 )

• patterning defects of the ventral spinal cord

abnormal embryonic neuroepithelium morphology ( J:178978 )

• striking loss of cilia in the spinal cord neuroectoderm

cardiovascular system

abnormal blood vessel morphology ( J:178978 )

• severe vascular defects

limbs/digits/tail

polydactyly ( J:178978 )

vision/eye

microphthalmia ( J:178978 )