All Phenotypes Dppa4<tm1.2Yam> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dppa4^tm1.2Yam
targeted mutation 1.2, Shinya Yamanaka
MGI:5298639

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Dppa2^tm1.1Yam/Dppa2^tm1.1Yam Dppa4^tm1.2Yam/Dppa4^tm1.2Yam	involves: 129S4/SvJae * FVB/N	MGI:5298645

Allelic Composition	Dppa2^tm1.1Yam/Dppa2^tm1.1Yam Dppa4^tm1.2Yam/Dppa4^tm1.2Yam
Genetic Background	involves: 129S4/SvJae * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dppa2^tm1.1Yam mutation (1 available); any Dppa2 mutation (27 available)
Dppa4^tm1.2Yam mutation (0 available); any Dppa4 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:178324 )

prenatal lethality, incomplete penetrance ( J:178324 )

• fewer embryos than expected are detected at E18.5

preweaning lethality, complete penetrance ( J:178324 )

• no double homozygotes pups are found at weaning

respiratory system

abnormal lung morphology ( J:178324 )

• at E18.5 the lung mesenchyme is thicker compared to controls

abnormal pulmonary alveolus morphology ( J:178324 )

• smaller alveolar spaces at E18.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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