Analysis Tools
vision/eye
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• four fold increase in degenerative spots on retinas compared to controls
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Allele Symbol Allele Name Allele ID |
Tg(RNU6-RNAi:Mpp5)13Wij transgene insertion 13, Jan Wijnholds MGI:5297927 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• four fold increase in degenerative spots on retinas compared to controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 1 and 3 months of age, ocular fundus exhibit sites of cellular mislocalization and roundish structures in the outer plexiform layer unlike wild-type mice
• at 6 and 12 months of age, the ocular fundus has spotty and patchy areas with vascular leakage unlike in wild-type mice
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• at P10, retinal basal infoldings are disorganization and vacuoles are increased in number and size compared with wild-type mice
• mice exhibit a stronger phenotype than in Tg(Chx10-EGFP/cre,-ALPP)2Clc Tg(RNU6-RNAi:Mpp5)13Wij mice
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• bipolar cells are ectopically localized in the outer nuclear layer
• at 3, 6, and 12 months, mice exhibit loss of photoreceptors and bipolar cells due to apoptosis compared with wild-type mice
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• the apical microvilli of the retinal pigment epithelium are either absent or shorter and did not interdigitate with the outer segments of photoreceptor cells compared to in wild-type mice
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• from P10 to P30, mice exhibit folds between the retinal outer and inner layers (ONL and INL) and retinal outer plexiform layer (OPL), half rosettes of photoreceptors in the ONL and OPL, and ectopic photoreceptor nuclei in the subretinal space unlike wild-type mice
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• ectopically localized in the subretinal space or outer plexiform layer
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• in the cone outer segments at P30
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• at 3, 6, and 12 months, mice exhibit loss of photoreceptors and bipolar cells due to apoptosis compared with wild-type mice
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• progressively thinner in aged mice
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• at P6
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• progressively thinner in aged mice
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• at P6
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• with roundish structures at 1 and 3 months
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• at P6
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• with gaps and irregularities
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• mice exhibit reduced scotopic and photopic responses and lowered a- and b-wave amplitudes compared with wild-type mice
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• mice exhibit reduced photopic response compared with wild-type mice
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• mice exhibit reduced scotopic response compared with wild-type mice
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• at P10, mice exhibit persistent apoptosis of photoreceptors and bipolar cells unlike wild-type mice
• at P18, mice exhibit increased apoptosis in the outer and inner nuclear layer compared with wild-type mice
• at 3, 6, and 12 months, mice exhibit loss of photoreceptors and bipolar cells due to apoptosis compared with wild-type mice
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• bipolar cells are ectopically localized in the outer nuclear layer
• at 3, 6, and 12 months, mice exhibit loss of photoreceptors and bipolar cells due to apoptosis compared with wild-type mice
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• ectopically localized in the subretinal space or outer plexiform layer
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• in the cone outer segments at P30
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• at 3, 6, and 12 months, mice exhibit loss of photoreceptors and bipolar cells due to apoptosis compared with wild-type mice
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• vascular leakage in the ocular fundus at 6 and 12 months of age
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• at P10, mice exhibit persistent apoptosis of photoreceptors and bipolar cells unlike wild-type mice
• at P18, mice exhibit increased apoptosis in the outer and inner nuclear layer compared with wild-type mice
• at 3, 6, and 12 months, mice exhibit loss of photoreceptors and bipolar cells due to apoptosis compared with wild-type mice
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• the apical microvilli of the retinal pigment epithelium are either absent or shorter and did not interdigitate with the outer segments of photoreceptor cells compared to in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit a milder phenotype than in Tg(RNU6-RNAi:Mpp5)13Wij Tg(rx3-icre)1Mjam mice
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• at 3 months of age, mice exhibit ectopic photoreceptor nuclei in the subretinal space unlike wild-type mice
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• at 12 months, the outer plexiform layer exhibit lamination defects
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• thinner at 12 months of age
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• in the outer plexiform layer
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• with sporadic gaps at 3 months of age
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• mice exhibit slightly reduced photopic response compared with wild-type mice
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• mice exhibit slightly reduced scotopic response compared with wild-type mice
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• in the outer plexiform layer
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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