Phenotypes associated with this allele

• Allele Symbol: bella
• Allele Name: bella
• Allele ID: MGI:5297598
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	bella/bella	involves: BALB/c * C3H/HeH	MGI:5297696
cx2	bella/bella Tg(CAG-Oxr1)#Ked/0	involves: BALB/c * C3H/HeH * C57BL/6 * CBA	MGI:5297697

Genotype
MGI:5297696

hm1

• Allelic Composition: bella/bella
• Genetic Background: involves: BALB/c * C3H/HeH

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Progressive neurodegeneration in the bella/bella mice

mortality/aging

premature death ( J:177995 )

• mice do not survive beyond P26

nervous system

increased neuron apoptosis ( J:177995 , J:230923 )

• in the granule cell layer of the cerebellum from P18 to P19 (J:177995)

decreased cerebellar granule cell number ( J:177995 )

• loss due to apoptosis

behavior/neurological

ataxia ( J:177995 )

• severe ataxic gait after P14

growth/size/body

postnatal growth retardation ( J:177995 )

• mice do not gain weight as fast as wild-type mice

muscle

centrally nucleated skeletal muscle fibers ( J:177995 )

• in the diaphragm but not the tibialis anterior or soleus muscles of the hindlimb

cellular

increased neuron apoptosis ( J:177995 , J:230923 )

• in the granule cell layer of the cerebellum from P18 to P19 (J:177995)

Genotype
MGI:5297697

cx2

• Allelic Composition: bella/bella; Tg(CAG-Oxr1)#Ked/0
• Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6 * CBA

mortality/aging

mortality/aging ( J:177995 )

N • mice survive beyond 8 months

behavior/neurological

behavior/neurological phenotype ( J:177995 )

N • mice do not exhibit ataxia

nervous system

nervous system phenotype ( J:177995 )

N • mice exhibit no cell death in the brain

growth/size/body

growth/size/body region phenotype ( J:177995 )

N • mice exhibit normal growth