About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sirt2tm1.1Cxd
targeted mutation 1.1, Chu-Xia Deng
MGI:5297582
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Sirt2tm1.1Cxd/Sirt2tm1.1Cxd either: (involves: C57BL/6 * FVB/N) or (involves: FVB/N * NIH Black Swiss) MGI:5297585


Genotype
MGI:5297585
hm1
Allelic
Composition
Sirt2tm1.1Cxd/Sirt2tm1.1Cxd
Genetic
Background
either: (involves: C57BL/6 * FVB/N) or (involves: FVB/N * NIH Black Swiss)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sirt2tm1.1Cxd mutation (0 available); any Sirt2 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• at 8 months in some male mice
• at 10 months in some female mice, primarily in the mammary glands
• at 20 months in more male mice in the liver, lung, pancreas, stomach, duodenum, and prostate
• at 24 in most female mice
• stomach tumor in one male mouse
• duodenum tumor in one male mice
• in one female and male mice
• poorly differentiated, with obvious nuclear polymorphisms
• in one female and male mice
• in some mice with extensive cellular proliferation
• in female and male mice

cellular
• in 35% of mouse embryonic fibroblasts
• in mouse embryonic fibroblasts
• in mouse embryonic fibroblasts
• mouse embryonic fibroblasts cease proliferating one passage before wild-type cells

endocrine/exocrine glands
• poorly differentiated, with obvious nuclear polymorphisms
• prior to tumor development
• in one female and male mice

integument
• poorly differentiated, with obvious nuclear polymorphisms
• prior to tumor development

reproductive system

digestive/alimentary system
• stomach tumor in one male mouse
• duodenum tumor in one male mice
• in one female and male mice

respiratory system
• in female and male mice

liver/biliary system
• in some mice with extensive cellular proliferation





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
04/23/2024
MGI 6.23
The Jackson Laboratory