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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd68tm1Xfen
targeted mutation 1, Xu Feng
MGI:5297542
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cd68tm1Xfen/Cd68tm1Xfen C57BL/6J-Cd68tm1Xfen MGI:5297546
ht2
 		Cd68tm1Xfen/Cd68+ C57BL/6J-Cd68tm1Xfen MGI:5297547


Genotype
MGI:5297546
hm1
Allelic
Composition		 Cd68tm1Xfen/Cd68tm1Xfen
Genetic
Background		 C57BL/6J-Cd68tm1Xfen
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd68tm1Xfen mutation (0 available); any Cd68 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Cd68tm1Xfen/Cd68tm1Xfen mice have increased trabecular bone and decreased trabecular tissue mineral density

skeleton
abnormal osteoclast morphology ( J:178120 )
• osteoclasts accumulate vesicle-like structures unlike wild-type cells
abnormal osteoclast physiology ( J:178120 )
• osteoclast adhesion to a cultured substrate is reduced compared with that of wild-type cells
decreased bone mineral density ( J:178120 )
• in trabecular, but not cortical, bone
abnormal trabecular bone morphology ( J:178120 )
• trabecular spacing is decreased compared to in wild-type mice
increased bone mineralization ( J:178120 )
• mineral apposition rate is increased compared to in wild-type mice

immune system
abnormal osteoclast morphology ( J:178120 )
• osteoclasts accumulate vesicle-like structures unlike wild-type cells
abnormal osteoclast physiology ( J:178120 )
• osteoclast adhesion to a cultured substrate is reduced compared with that of wild-type cells

hematopoietic system
abnormal osteoclast morphology ( J:178120 )
• osteoclasts accumulate vesicle-like structures unlike wild-type cells
abnormal osteoclast physiology ( J:178120 )
• osteoclast adhesion to a cultured substrate is reduced compared with that of wild-type cells




Genotype
MGI:5297547
ht2
Allelic
Composition		 Cd68tm1Xfen/Cd68+
Genetic
Background		 C57BL/6J-Cd68tm1Xfen
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd68tm1Xfen mutation (0 available); any Cd68 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Increased bone volume in Cd68tm1Xfen/Cd68tm1Xfen mice and increased mineral apposition rate in Cd68tm1Xfen/Cd68+ and Cd68tm1Xfen/Cd68tm1Xfen mice

skeleton
increased bone mineralization ( J:178120 )
• mineral apposition rate is increased compared to in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory