Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation
(2 available)
Tnfsf11tm1.1Caob mutation
(1 available);
any
Tnfsf11 mutation
(30 available)
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skeleton
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N |
• mice treated with doxycycline until 4 months of age exhibit normal cancellous architecture at 6 months
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• in all mice
• however, exposure to doxycycline restores tooth eruption
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• mice exhibit unresorbed cartilage unlike wild-type mice
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• widened growth plate in the femur
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craniofacial
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• in all mice
• however, exposure to doxycycline restores tooth eruption
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growth/size/body
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• in all mice
• however, exposure to doxycycline restores tooth eruption
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(BGLAP-cre)1Clem mutation
(1 available)
Tnfsf11tm1.1Caob mutation
(1 available);
any
Tnfsf11 mutation
(30 available)
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skeleton
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• mice exhibit unresorbed cartilage unlike wild-type mice
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• widened growth plate in the femur
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craniofacial
growth/size/body
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Prrx1-cre)1Cjt mutation
(2 available)
Tnfsf11tm1.1Caob mutation
(1 available);
any
Tnfsf11 mutation
(30 available)
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skeleton
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N |
• mice exhibit normal bone mass and tooth eruption
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• in the femur but not the spine
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• mice exhibit unresorbed cartilage unlike wild-type mice
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• widened growth plate in the femur
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immune system
hematopoietic system
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Col10a1-cre)1427Vdm mutation
(0 available)
Tnfsf11tm1.1Caob mutation
(1 available);
any
Tnfsf11 mutation
(30 available)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Dmp1-cre)1Jqfe mutation
(4 available)
Tnfsf11tm1.1Caob mutation
(1 available);
any
Tnfsf11 mutation
(30 available)
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skeleton
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N |
• mice exhibit normal tooth eruption and growth plates
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• mice suspended by their tails for 3 weeks are protected from loss of bone and changes in cancellous architecture compared with similarly treated wild-type mice
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• mice suspended by their tails for 3 weeks do not exhibit an increase in osteoclast number compared with similarly treated wild-type mice
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• BMD increases progressively in the spine
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• BMD increases progressively in the femur
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• at 6 months of age in the femur and spine
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• in mice suspended by their tails for 3 weeks
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• mice suspended by their tails for 3 weeks exhibit increased trabecular spacing compared with similarly treated wild-type mice
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immune system
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• mice suspended by their tails for 3 weeks do not exhibit an increase in osteoclast number compared with similarly treated wild-type mice
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hematopoietic system
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• mice suspended by their tails for 3 weeks do not exhibit an increase in osteoclast number compared with similarly treated wild-type mice
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Analysis Tools