All Phenotypes Tnfsf11<tm1.1Caob> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tnfsf11^tm1.1Caob
targeted mutation 1.1, Charles O'Brien
MGI:5297355

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tnfsf11^tm1.1Caob/Tnfsf11^tm1.1Caob Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0	involves: 129S * 129X1/SvJ * C57BL/6 * CD-1	MGI:5297382
cn2	Tnfsf11^tm1.1Caob/Tnfsf11^tm1.1Caob Tg(BGLAP-cre)1Clem/0	involves: 129S * 129X1/SvJ * C57BL/6 * FVB/NJ	MGI:5297378
cn3	Tnfsf11^tm1.1Caob/Tnfsf11^tm1.1Caob Tg(Prrx1-cre)1Cjt/0	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6	MGI:5297381
cn4	Tnfsf11^tm1.1Caob/Tnfsf11^tm1.1Caob Tg(Col10a1-cre)1427Vdm/0	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6	MGI:5297383
cn5	Tnfsf11^tm1.1Caob/Tnfsf11^tm1.1Caob Tg(Dmp1-cre)1Jqfe/0	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * FVB	MGI:5297380

Allelic Composition	Tnfsf11^tm1.1Caob/Tnfsf11^tm1.1Caob Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background	involves: 129S * 129X1/SvJ * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation (7 available)
Tnfsf11^tm1.1Caob mutation (1 available); any Tnfsf11 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:177558 )

N	• mice treated with doxycycline until 4 months of age exhibit normal cancellous architecture at 6 months

failure of tooth eruption ( J:177558 )

• in all mice

• however, exposure to doxycycline restores tooth eruption

increased bone mineral density ( J:177558 )

• at 5 weeks of age

increased trabecular bone volume ( J:177558 )

• at 5 weeks of age

abnormal cartilage morphology ( J:177558 )

• mice exhibit unresorbed cartilage unlike wild-type mice

increased long bone epiphyseal plate size ( J:177558 )

• widened growth plate in the femur

craniofacial

failure of tooth eruption ( J:177558 )

• in all mice

• however, exposure to doxycycline restores tooth eruption

growth/size/body

failure of tooth eruption ( J:177558 )

• in all mice

• however, exposure to doxycycline restores tooth eruption

Allelic Composition	Tnfsf11^tm1.1Caob/Tnfsf11^tm1.1Caob Tg(BGLAP-cre)1Clem/0
Genetic Background	involves: 129S * 129X1/SvJ * C57BL/6 * FVB/NJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(BGLAP-cre)1Clem mutation (3 available)
Tnfsf11^tm1.1Caob mutation (1 available); any Tnfsf11 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

failure of tooth eruption ( J:177558 )

• in some mice

increased bone mineral density ( J:177558 )

• at 5 weeks of age

increased trabecular bone volume ( J:177558 )

• at 5 weeks of age

abnormal cartilage morphology ( J:177558 )

• mice exhibit unresorbed cartilage unlike wild-type mice

increased long bone epiphyseal plate size ( J:177558 )

• widened growth plate in the femur

craniofacial

failure of tooth eruption ( J:177558 )

• in some mice

growth/size/body

failure of tooth eruption ( J:177558 )

• in some mice

Allelic Composition	Tnfsf11^tm1.1Caob/Tnfsf11^tm1.1Caob Tg(Prrx1-cre)1Cjt/0
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Prrx1-cre)1Cjt mutation (2 available)
Tnfsf11^tm1.1Caob mutation (1 available); any Tnfsf11 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:177558 )

N	• mice exhibit normal bone mass and tooth eruption

decreased osteoclast cell number ( J:177558 )

• absent in femur

increased bone mineral density ( J:177558 )

increased trabecular bone volume ( J:177558 )

• in the femur but not the spine

osteopetrosis ( J:177558 )

• severe

abnormal cartilage morphology ( J:177558 )

• mice exhibit unresorbed cartilage unlike wild-type mice

increased long bone epiphyseal plate size ( J:177558 )

• widened growth plate in the femur

immune system

decreased osteoclast cell number ( J:177558 )

• absent in femur

hematopoietic system

decreased osteoclast cell number ( J:177558 )

• absent in femur

Allelic Composition	Tnfsf11^tm1.1Caob/Tnfsf11^tm1.1Caob Tg(Col10a1-cre)1427Vdm/0
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Col10a1-cre)1427Vdm mutation (0 available)
Tnfsf11^tm1.1Caob mutation (1 available); any Tnfsf11 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

increased bone mineral density ( J:177558 )

increased trabecular bone volume ( J:177558 )

osteopetrosis ( J:177558 )

Allelic Composition	Tnfsf11^tm1.1Caob/Tnfsf11^tm1.1Caob Tg(Dmp1-cre)1Jqfe/0
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Dmp1-cre)1Jqfe mutation (9 available)
Tnfsf11^tm1.1Caob mutation (1 available); any Tnfsf11 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:177558 )

N	• mice exhibit normal tooth eruption and growth plates

abnormal bone structure ( J:177558 )

• mice suspended by their tails for 3 weeks are protected from loss of bone and changes in cancellous architecture compared with similarly treated wild-type mice

abnormal osteoclast cell number ( J:177558 )

• mice suspended by their tails for 3 weeks do not exhibit an increase in osteoclast number compared with similarly treated wild-type mice

decreased osteoclast cell number ( J:177558 )

increased bone mineral density of vertebrae ( J:177558 )

• BMD increases progressively in the spine

increased bone mineral density of femur ( J:177558 )

• BMD increases progressively in the femur

increased trabecular bone volume ( J:177558 )

• at 6 months of age in the femur and spine

decreased compact bone thickness ( J:177558 )

• in mice suspended by their tails for 3 weeks

increased bone trabecular spacing ( J:177558 )

• mice suspended by their tails for 3 weeks exhibit increased trabecular spacing compared with similarly treated wild-type mice

immune system

abnormal osteoclast cell number ( J:177558 )

• mice suspended by their tails for 3 weeks do not exhibit an increase in osteoclast number compared with similarly treated wild-type mice

decreased osteoclast cell number ( J:177558 )

hematopoietic system

abnormal osteoclast cell number ( J:177558 )

• mice suspended by their tails for 3 weeks do not exhibit an increase in osteoclast number compared with similarly treated wild-type mice

decreased osteoclast cell number ( J:177558 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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