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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sgcetm1Vinni
targeted mutation 1, Vincenzo Nigro
MGI:5296936
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sgcetm1Vinni/Sgcetm1Vinni B6.129P2-Sgcetm1Vinni MGI:5296943
cx2
 		Sgcatm1Kcam/Sgcatm1Kcam
Sgcetm1Vinni/Sgcetm1Vinni 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:5296946


Genotype
MGI:5296943
hm1
Allelic
Composition		 Sgcetm1Vinni/Sgcetm1Vinni
Genetic
Background		 B6.129P2-Sgcetm1Vinni
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sgcetm1Vinni mutation (1 available); any Sgce mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:177563 )
N
• mice exhibit normal heart morphology




Genotype
MGI:5296946
cx2
Allelic
Composition		 Sgcatm1Kcam/Sgcatm1Kcam
Sgcetm1Vinni/Sgcetm1Vinni
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sgcatm1Kcam mutation (4 available); any Sgca mutation (26 available)
Sgcetm1Vinni mutation (1 available); any Sgce mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiac muscle necrosis ( J:177563 )
• at 2 months of age
• severe at 1 year of age
abnormal heart left ventricle morphology ( J:177563 )
• mice exhibit increased left ventricular end diastolic diameter and left ventricular end systolic diameter compared with wild-type mice
cardiac fibrosis ( J:177563 )
• at 6 months of age
• severe at 1 year of age
decreased cardiac muscle contractility ( J:177563 )
• reduced fractional shortening and ejection fraction
cardiomyopathy ( J:177563 )
• at 2 months of age with large areas of necrotic areas, inflammatory infiltration, and centralized nuclei
• exercise worsens cardiac pathology

immune system

muscle
muscle phenotype ( J:177563 )
N
• mice exhibit normal diaphragm morphology
cardiac muscle necrosis ( J:177563 )
• at 2 months of age
• severe at 1 year of age
decreased cardiac muscle contractility ( J:177563 )
• reduced fractional shortening and ejection fraction
cardiomyopathy ( J:177563 )
• at 2 months of age with large areas of necrotic areas, inflammatory infiltration, and centralized nuclei
• exercise worsens cardiac pathology

cellular
cardiac muscle necrosis ( J:177563 )
• at 2 months of age
• severe at 1 year of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory