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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gucy1b1tm1Zhen
targeted mutation 1, Zhenyu Li
MGI:5296786
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gucy1b1tm1Zhen/Gucy1b1tm1Zhen B6.129P2-Gucy1b1tm1Zhen MGI:5296794
cn2
 		Gucy1b1tm1Zhen/Gucy1b1tm1Zhen
Tg(Pf4-icre)Q3Rsko/0 		involves: 129P2/OlaHsd * C57BL/6J MGI:5296796


Genotype
MGI:5296794
hm1
Allelic
Composition		 Gucy1b1tm1Zhen/Gucy1b1tm1Zhen
Genetic
Background		 B6.129P2-Gucy1b1tm1Zhen
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gucy1b1tm1Zhen mutation (1 available); any Gucy1b1 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:177066 )
• mice are viable and fertile




Genotype
MGI:5296796
cn2
Allelic
Composition		 Gucy1b1tm1Zhen/Gucy1b1tm1Zhen
Tg(Pf4-icre)Q3Rsko/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gucy1b1tm1Zhen mutation (1 available); any Gucy1b1 mutation (42 available)
Tg(Pf4-icre)Q3Rsko mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal platelet physiology ( J:177066 )
• NO-induced cGMP production is abolished in platelets compared to in control cells
• agonist-induced cGMP production is reduced in platelets compared to in control cells
decreased platelet aggregation ( J:177066 )
• collagen- or thrombin-induced platelet secretion and aggregation are attenuated unlike in control cells
• however, high concentrations of agonists induce normal aggregation
decreased susceptibility to induced thrombosis ( J:177066 )
• time to form FeCl3-induced carotid artery thrombosis is prolonged compared to in control mice

cardiovascular system
cardiovascular system phenotype ( J:177066 )
N
• mice exhibit normal blood pressure

hematopoietic system
hematopoietic system phenotype ( J:177066 )
N
• mice exhibit normal blood counts, including platelets
abnormal platelet physiology ( J:177066 )
• NO-induced cGMP production is abolished in platelets compared to in control cells
• agonist-induced cGMP production is reduced in platelets compared to in control cells
decreased platelet aggregation ( J:177066 )
• collagen- or thrombin-induced platelet secretion and aggregation are attenuated unlike in control cells
• however, high concentrations of agonists induce normal aggregation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory