Phenotypes associated with this allele

• Allele Symbol: Mcm10^tm1Hlee
• Allele Name: targeted mutation 1, Ho Lee
• Allele ID: MGI:5296322
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mcm10^tm1Hlee/Mcm10^tm1Hlee	involves: 129P2/OlaHsd * C57BL/6	MGI:5296323

Genotype
MGI:5296323

hm1

• Allelic Composition: Mcm10^tm1Hlee/Mcm10^tm1Hlee
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, incomplete penetrance ( J:177618 )

• some mice die by E3.5

embryonic lethality between implantation and placentation, complete penetrance ( J:177618 )

• mice tend to be completely resorbed at E7.5

• no mice are recovered at E8.5

embryo

increased embryonic tissue cell apoptosis ( J:177618 )

• in E2.5 embryos

embryonic growth arrest ( J:177618 )

• in culture, morula staged embryos cease growing and die unlike wild-type embryos

abnormal blastocyst morphology ( J:177618 )

• small at E3.5

abnormal blastocoele morphology ( J:177618 )

• small at E3.5

abnormal inner cell mass morphology ( J:177618 )

• small at E3.5

cellular

increased embryonic tissue cell apoptosis ( J:177618 )

• in E2.5 embryos

decreased cell proliferation ( J:177618 )

• in cultured E2.5 embryos