Phenotypes associated with this allele

• Allele Symbol: Sirt2^tm1.1Auw
• Allele Name: targeted mutation 1.1, Johan Auwerx
• Allele ID: MGI:5295483
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sirt2^tm1.1Auw/Sirt2^tm1.1Auw	involves: 129 * C57BL/6J	MGI:5295751
cn2	Sirt2^tm1.1Auw/Sirt2^tm1.1Auw Tg(Mpz-cre)26Mes/0	involves: 129 * C57BL/6J * FVB/N	MGI:5295752

Genotype
MGI:5295751

hm1

• Allelic Composition: Sirt2^tm1.1Auw/Sirt2^tm1.1Auw
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:177468 )

Genotype
MGI:5295752

cn2

• Allelic Composition: Sirt2^tm1.1Auw/Sirt2^tm1.1Auw; Tg(Mpz-cre)26Mes/0
• Genetic Background: involves: 129 * C57BL/6J * FVB/N

Sirt2^tm1.1Auw/Sirt2^tm1.1Auw Tg(Mpz-cre)26Mes/0 mice display hypomyelination

nervous system

abnormal myelination ( J:177468 )

• mice exhibit a transient delay in myelination compared with wild-type mice

• the sciatic nerve is hypomyelinated at P1, P3, and P5

• at P21 and P28, mice exhibit extensive outfoldings in compact myelin located in close vicinity to the paranode

• following nerve crush injury, mice exhibit reduced myelination compared with wild-type mice

• however, mice exhibit normal myelination at P7 and remyelination following nerve crush injury after 28 days

decreased nerve conduction velocity ( J:177468 )

• at P21 and P28

homeostasis/metabolism

abnormal response to injury ( J:177468 )

• remyelination following nerve crush injury is delayed compared to in wild-type mice

• however, axon regeneration is normal

behavior/neurological

behavior/neurological phenotype ( J:177468 )

N • mice exhibit normal function on a rotarod, grip strength, and thermal nociception