All Phenotypes Col1a1<tm1(CAG-Sirt2)Jmi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Col1a1^{tm1(CAG-Sirt2)Jmi}
targeted mutation 1, Jeffrey Milbrandt
MGI:5295482

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Col1a1^{tm1(CAG-Sirt2)Jmi}/Col1a1⁺ Tg(Mpz-cre)26Mes/0	involves: 129S4/SvJae * C57BL/6 * FVB/N	MGI:5295750

Allelic Composition	Col1a1^{tm1(CAG-Sirt2)Jmi}/Col1a1⁺ Tg(Mpz-cre)26Mes/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1^{tm1(CAG-Sirt2)Jmi} mutation (1 available); any Col1a1 mutation (166 available)
Tg(Mpz-cre)26Mes mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Delayed remyelination after nerve crush injury in Col1a1^{tm1(CAG-Sirt2)Jmi}/Col1a1^{tm1(CAG-Sirt2)Jmi} Tg(Mpz-cre)26Mes/0 mice

nervous system

abnormal response to nerve crush injury ( J:177468 )

• remyelination following nerve crush injury is delayed compared to in wild-type mice

• however, axon regeneration is normal

abnormal myelination ( J:177468 )

• remyelination following nerve crush injury is delayed compared to in wild-type mice

homeostasis/metabolism

abnormal response to nerve crush injury ( J:177468 )

• remyelination following nerve crush injury is delayed compared to in wild-type mice

• however, axon regeneration is normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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