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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Col1a1tm1(CAG-Sirt2)Jmi
targeted mutation 1, Jeffrey Milbrandt
MGI:5295482
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Col1a1tm1(CAG-Sirt2)Jmi/Col1a1+
Tg(Mpz-cre)26Mes/0 		involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:5295750


Genotype
MGI:5295750
cn1
Allelic
Composition		 Col1a1tm1(CAG-Sirt2)Jmi/Col1a1+
Tg(Mpz-cre)26Mes/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm1(CAG-Sirt2)Jmi mutation (1 available); any Col1a1 mutation (160 available)
Tg(Mpz-cre)26Mes mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Delayed remyelination after nerve crush injury in Col1a1tm1(CAG-Sirt2)Jmi/Col1a1tm1(CAG-Sirt2)Jmi Tg(Mpz-cre)26Mes/0 mice

homeostasis/metabolism
abnormal response to injury ( J:177468 )
• remyelination following nerve crush injury is delayed compared to in wild-type mice
• however, axon regeneration is normal

nervous system
abnormal myelination ( J:177468 )
• remyelination following nerve crush injury is delayed compared to in wild-type mice




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory