Phenotypes associated with this allele

• Allele Symbol: Hcn2^tm1.2Lex
• Allele Name: targeted mutation 1.2, Lexicon Genetics
• Allele ID: MGI:5295435
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hcn2^tm1.2Lex/Hcn2^tm1.2Lex	involves: BALB/cJ * C57BL/6	MGI:5295438

Genotype
MGI:5295438

hm1

• Allelic Composition: Hcn2^tm1.2Lex/Hcn2^tm1.2Lex
• Genetic Background: involves: BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:176663 )

• mice seldom live beyond six weeks

nervous system

abnormal action potential ( J:176663 )

• FSK and PGE2 fail to accelerate action potential firing unlike in wild-type cells

abnormal neuron physiology ( J:176663 )

• inward current after membrane hyperpolarization is smaller than in control mice

• in voltage-clamped neurons, the activation rate of inward current after polarization voltage is faster than in wild-type cells

• neurons fail to exhibit an increase in cAMP after depolarization unlike in wild-type cells

behavior/neurological

ataxia ( J:176663 )