Phenotypes associated with this allele

• Allele Symbol: Lrrk2^tm1.1Npa
• Allele Name: targeted mutation 1.1, Novartis Pharma AG
• Allele ID: MGI:5295368
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lrrk2^tm1.1Npa/Lrrk2^tm1.1Npa	either: B6.C-Lrrk2^tm1.1Npa or (involves: BALB/c * C57BL/6J)	MGI:5295391

Genotype
MGI:5295391

hm1

• Allelic Composition: Lrrk2^tm1.1Npa/Lrrk2^tm1.1Npa
• Genetic Background: either: B6.C-Lrrk2^tm1.1Npa or (involves: BALB/c * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:176679 )

N • mice exhibit normal systolic blood pressure and heart rate

increased systemic arterial diastolic blood pressure ( J:176679 )

behavior/neurological

behavior/neurological phenotype ( J:176679 )

N • mice exhibit normal locomotor response to dopamine agonists/antagonists

nervous system

nervous system phenotype ( J:176679 )

N • mice exhibit no overt neuropathy in response to dopamine agonists/antagonists