Analysis Tools
mortality/aging
|
• no mice survive beyond 14 days post treatment with DSS to induce colitis
• however, mice treated with a neutrophil elastase inhibition recover from DSS-induced colitis
|
digestive/alimentary system
| N |
• mice exhibit normal intestinal barrier function and colonic microbiota
|
|
• DSS-treated mice fail to recover from induced colitis compared with similarly treated wild-type mice
• however, mice exhibit normal onset, severity, and sensitivity to DSS-induced colitis with normal cytokine profile, and mice treated with a neutrophil elastase inhibition recover from DSS-induced colitis
|
growth/size/body
weight loss
(
J:175844
)
|
• DSS-treated mice exhibit perisstent weight loss unlike similarly treated wild-type mice
|
immune system
| N |
• mice exhibit normal regulatory T cell numbers and activation of dendritic cells
|
|
• DSS-treated mice fail to recover from induced colitis compared with similarly treated wild-type mice
• however, mice exhibit normal onset, severity, and sensitivity to DSS-induced colitis with normal cytokine profile, and mice treated with a neutrophil elastase inhibition recover from DSS-induced colitis
|
homeostasis/metabolism
|
• no mice survive beyond 14 days post treatment with DSS to induce colitis
• however, mice treated with a neutrophil elastase inhibition recover from DSS-induced colitis
|
