Phenotypes associated with this allele

• Allele Symbol: Pmel^tm1.1Sson
• Allele Name: targeted mutation 1.1, Leif Andersson
• Allele ID: MGI:5294792
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pmel^tm1.1Sson/Pmel^tm1.1Sson	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6	MGI:5294794

Genotype
MGI:5294794

hm1

• Allelic Composition: Pmel^tm1.1Sson/Pmel^tm1.1Sson
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Altered shape of melanosomes in Pmel^tm1.1Sson/Pmel^tm1.1Sson skin

pigmentation

abnormal tail hair pigmentation ( J:177116 )

• reduced tail pigmentation in mice on a black or agouti background

diluted coat color ( J:177116 )

• weak silvering effect in the coat color and reduced tail and paw pigmentation in mice on a black background

• marked dilution on a brown background

• on a brown agouti background dilution of the dark hairs is seen

• decrease in eumelanin content in the hair but no significant effect on pheomelanin content

abnormal melanosome morphology ( J:177116 )

• skin, choroid, and retinal melanosomes are spherical

• no fibrillar intermediates are detected in melaocytes

• many of the melanosomes are associated with dense, granular deposits of melanin rather than the smooth, fibrillar deposits

abnormal choroid melanin granule morphology ( J:177116 )

• spherical melanosomes

abnormal retina melanin granule morphology ( J:177116 )

• spherical melanosomes

integument

abnormal tail hair pigmentation ( J:177116 )

• reduced tail pigmentation in mice on a black or agouti background

diluted coat color ( J:177116 )

• weak silvering effect in the coat color and reduced tail and paw pigmentation in mice on a black background

• marked dilution on a brown background

• on a brown agouti background dilution of the dark hairs is seen

• decrease in eumelanin content in the hair but no significant effect on pheomelanin content

vision/eye

abnormal choroid melanin granule morphology ( J:177116 )

• spherical melanosomes

abnormal retina melanin granule morphology ( J:177116 )

• spherical melanosomes