All Phenotypes Lin28a<tm1Gqda> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lin28a^tm1Gqda
targeted mutation 1, George Q Daley
MGI:5294611

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Lin28a^tm1Gqda/Lin28a^tm1.1Gqda Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0	involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N	MGI:5519072
cn2	Lin28a^tm1Gqda/Lin28a^tm1Gqda Myf5^tm1(cre)Mrc/Myf5⁺	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	MGI:5519078
cn3	Lin28a^tm1Gqda/Lin28a^tm1Gqda Myf5^tm3(cre)Sor/Myf5⁺	involves: 129S4/SvJae * C57BL/6 * CD-1	MGI:5294786

Allelic Composition	Lin28a^tm1Gqda/Lin28a^tm1.1Gqda Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0
Genetic Background	involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lin28a^tm1.1Gqda mutation (1 available); any Lin28a mutation (76 available)
Lin28a^tm1Gqda mutation (0 available); any Lin28a mutation (76 available)
Ndor1^{Tg(UBC-cre/ERT2)1Ejb} mutation (6 available); any Ndor1 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:199720 )

N	• mice exhibit normal growth when treated with tamoxifen at 7 to 9 days or 6 weeks of age

decreased body size ( J:199720 )

• dwarfism in male mice treated with tamoxifen at E15.5, but not as severe as in Lin28a^tm1.1Gqda homozygotes

• however, female mice exhibit normal growth

decreased body length ( J:199720 )

• dwarfism in male mice treated with tamoxifen at E15.5

• however, female mice exhibit normal growth

Allelic Composition	Lin28a^tm1Gqda/Lin28a^tm1Gqda Myf5^tm1(cre)Mrc/Myf5⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lin28a^tm1Gqda mutation (0 available); any Lin28a mutation (76 available)
Myf5^tm1(cre)Mrc mutation (1 available); any Myf5 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:199720 )

N	• mice exhibit normal size

Allelic Composition	Lin28a^tm1Gqda/Lin28a^tm1Gqda Myf5^tm3(cre)Sor/Myf5⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lin28a^tm1Gqda mutation (0 available); any Lin28a mutation (76 available)
Myf5^tm3(cre)Sor mutation (1 available); any Myf5 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

impaired glucose tolerance ( J:177113 )

insulin resistance ( J:177113 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23