Phenotypes associated with this allele

• Allele Symbol: Map3k12^tm1Lewc
• Allele Name: targeted mutation 1, Joseph W Lewcock
• Allele ID: MGI:5294467
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Map3k12^tm1Lewc/Map3k12^tm1Lewc Tg(CAG-cre/Esr1*)5Amc/0	involves: C57BL/6 * CBA	MGI:5502227

Genotype
MGI:5502227

cn1

• Allelic Composition: Map3k12^tm1Lewc/Map3k12^tm1Lewc; Tg(CAG-cre/Esr1*)5Amc/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased retina ganglion cell number ( J:196076 )

• 6 weeks after optic nerve crush, tamoxifen-treated mice retain their ganglion cell axons and show only 13% loss of ganglion cell layer neurons compared to control animals which show a reduction in ganglion cell axons and a 44% loss of ganglion cell layer neurons; protection of retinal ganglion cell neurons persists at 18 weeks after injury

vision/eye

decreased retina ganglion cell number ( J:196076 )

• 6 weeks after optic nerve crush, tamoxifen-treated mice retain their ganglion cell axons and show only 13% loss of ganglion cell layer neurons compared to control animals which show a reduction in ganglion cell axons and a 44% loss of ganglion cell layer neurons; protection of retinal ganglion cell neurons persists at 18 weeks after injury