Analysis Tools
mortality/aging
| N |
• Background Sensitivity: mice maintained on a 129S2 background exhibit normal viability compared with mice maintained on a C57BL/6 background
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reproductive system
| N |
• Background Sensitivity: mice maintained on a 129S2 background exhibit normal fertility compared with mice maintained on a C57BL/6 background
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nervous system
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• following closure of the contralateral eye for 6 days during the critical period (P26-P28) or monocular deprivation in adults, mice exhibit impaired late-phase ocular dominance plasticity measured by optical imaging of intrinsic signals compared with wild-type
• however, mice exhibit normal response after 2 days of closure during the critical period
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• after being dark-reared, mice do not exhibit an increase in spine density in pyramidal neurons unlike wild-type mice
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• at P34 (but not at P28), anesthetized mice exhibit increased firing rates in the binocular region of primary visual cortex compared with wild-type mice
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• under normal rearing conditions or after 6 days of monocular deprivation, the frequency of action potential firing in response to a series of depolarizing current steps (f-I curve) exhibits a leftward shift compared with wild-type mice
• however, response after 2 days of monocular deprivation is normal
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• following monocular deprivation for 6 days at P26-P28 or P32, mEPSC amplitude in layer 2/3 pyramidal neurons does not increase as in wild-type mice
• following monocular deprivation for 2 or 6 days at P26-P28 or P32, mEPSC frequency in layer 2/3 pyramidal neurons is decreased compared to in wild-type mice
• however, response after 2 days of monocular deprivation is normal
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• following monocular deprivation for 6 days at P26-P28 or P32, mIPSC frequency is increased compared to in wild-type mice
• however, mIPSC amplitude is normal at 2 and 6 days of monocular deprivation
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behavior/neurological
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• following closure of the contralateral eye for 6 days during the critical period (P26-P28), mice exhibit increased eye response in both the contralateral (deprived) and ipsilateral (open) eyes unlike wild-type mice
• however, response after 2 days of during the critical period closure is normal
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vision/eye
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• following closure of the contralateral eye for 6 days during the critical period (P26-P28), mice exhibit increased eye response in both the contralateral (deprived) and ipsilateral (open) eyes unlike wild-type mice
• however, response after 2 days of during the critical period closure is normal
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