All Phenotypes Fgf9<Aca12> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgf9^Aca12/Fgf9^Aca12	involves: C57BL/6J	MGI:5293830
ht2	Fgf9^Aca12/Fgf9⁺	involves: C57BL/6J	MGI:5293831

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:176356 )

N	• unlike mice homozygous for a null mutation, mice are viable

vision/eye

vision/eye phenotype ( J:176356 )

N	• no retinal defects are detected

increased eye anterior chamber depth ( J:176356 )

• increase in anterior chamber depth in males and females

abnormal lens development ( J:176356 )

• delay in primary lens fiber growth at E12.5

• at E15.5 the connections between lens fiber cells and lens epithelium is partly disrupted

• decrease in prenatal lens growth

cataract ( J:176356 )

• at 12 months of age 11 of 18 mice display faint opacities of fiber cells at the anterior pole, indicating a tendency towards age related cataract formation

small lens ( J:176356 )

• decrease in mean lens polar and equatorial diameters at E12.5 and E15.5

• decrease in lens thickness at 11 weeks of age in males and females

• axial length is decreased at 11 weeks of age in males and females

• phenotypes are more severe in homozygous mice compared to heterozygous mice

abnormal vision ( J:176356 )

• decrease in mean spatial frequency at 3 months of age

reproductive system

reproductive system phenotype ( J:176356 )

N	• unlike mice homozygous for a null mutation, no defects in sex determination are detected

skeleton

skeleton phenotype ( J:176356 )

N	• unlike mice homozygous for a null mutation, skeletogenesis is normal

Allelic Composition	Fgf9^Aca12/Fgf9⁺
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf9^Aca12 mutation (1 available); any Fgf9 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype